Perturbations of native membrane protein structure in alkyl phosphocholine detergents: a critical assessment of NMR and biophysical studies
Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …
Membrane protein structure and dynamics from NMR spectroscopy
We review the current state of membrane protein structure determination using solid-state
nuclear magnetic resonance (NMR) spectroscopy. Multidimensional magic-angle-spinning …
nuclear magnetic resonance (NMR) spectroscopy. Multidimensional magic-angle-spinning …
Allosteric regulation of SERCA by phosphorylation-mediated conformational shift of phospholamban
M Gustavsson, R Verardi, DG Mullen… - Proceedings of the …, 2013 - National Acad Sciences
The membrane protein complex between the sarcoplasmic reticulum Ca2+-ATPase
(SERCA) and phospholamban (PLN) controls Ca2+ transport in cardiomyocytes, thereby …
(SERCA) and phospholamban (PLN) controls Ca2+ transport in cardiomyocytes, thereby …
Solution NMR of membrane proteins: practice and challenges
CR Sanders, F Sönnichsen - Magnetic Resonance in …, 2006 - Wiley Online Library
This review focuses upon the application of solution NMR methods to multispan integral
membrane proteins, particularly with respect to determination of global folds by this …
membrane proteins, particularly with respect to determination of global folds by this …
Determining membrane protein structures: still a challenge!
JJ Lacapere, E Pebay-Peyroula, JM Neumann… - Trends in biochemical …, 2007 - cell.com
Determination of structures and dynamics events of transmembrane proteins is important for
the understanding of their function. Analysis of such events requires high-resolution 3D …
the understanding of their function. Analysis of such events requires high-resolution 3D …
Structural topology of phospholamban pentamer in lipid bilayers by a hybrid solution and solid-state NMR method
Phospholamban (PLN) is a type II membrane protein that inhibits the sarcoplasmic reticulum
Ca2+-ATPase (SERCA), thereby regulating calcium homeostasis in cardiac muscle. In …
Ca2+-ATPase (SERCA), thereby regulating calcium homeostasis in cardiac muscle. In …
Solid‐state NMR spectroscopy on complex biomolecules
M Renault, A Cukkemane… - Angewandte Chemie …, 2010 - Wiley Online Library
Biomolecular applications of NMR spectroscopy are often merely associated with soluble
molecules or magnetic resonance imaging. However, since the late 1970s, solid‐state NMR …
molecules or magnetic resonance imaging. However, since the late 1970s, solid‐state NMR …
NMR structure of the cathelicidin-derived human antimicrobial peptide LL-37 in dodecylphosphocholine micelles
LL-37 is the only cathelicidin-derived polypeptide found in humans. Its eclectic function
makes this peptide one of the most intriguing chemical defense agents, with crucial roles in …
makes this peptide one of the most intriguing chemical defense agents, with crucial roles in …
Structures of Rat and Human Islet Amyloid Polypeptide IAPP1−19 in Micelles by NMR Spectroscopy
Disruption of the cellular membrane by the amyloidogenic peptide IAPP (or amylin) has
been implicated in β-cell death during type 2 diabetes. While the structure of the mostly inert …
been implicated in β-cell death during type 2 diabetes. While the structure of the mostly inert …
Structure and topology of monomeric phospholamban in lipid membranes determined by a hybrid solution and solid-state NMR approach
Phospholamban (PLN) is an essential regulator of cardiac muscle contractility. The
homopentameric assembly of PLN is the reservoir for active monomers that, upon …
homopentameric assembly of PLN is the reservoir for active monomers that, upon …