Programmed cell death is a genetically regulated process of cell suicide that is central to the
development, homeostasis and integrity of multicellular organisms. Conversely, the …

Unicellular, planktonic, prokaryotic and eukaryotic photoautotrophs (phytoplankton) have an
ancient evolutionary history on Earth during which time they have played key roles in the …

ABSTRACT Miltefosine (hexadecylphosphocholine [HePC]) has proved to be a potent oral
treatment for human visceral leishmaniasis due to Leishmania donovani. The molecular …

Phytoplankton evolved in the Archaean oceans more than 2.8 billion years ago and are of
crucial importance in regulating aquatic food webs, biogeochemical cycles and the Earth's …

Miltefosine causes leishmanial death, but the possible mechanism (s) of action is not known.
The mode of action of miltefosine was investigated in vitro in Leishmania donovani …

The phenotypic and biochemical similarities between caspase-mediated apoptosis and
cellular differentiation are striking. They include such diverse phenomenon as mitochondrial …

A major impediment to effective anti-leishmanial chemotherapy is the emergence of drug
resistance, especially to sodium antimony gluconate, the first-line treatment for …

Leishmania mexicana amastigotes are particularly rich in cysteine peptidases (CPs), which
play important roles in facilitating the survival and growth of the parasites in mammals. The …

Among the waterborne protozoan parasites of medical and veterinary importance,
Blastocystis is perhaps one of the less well-understood. However, in recent years, there has …

The family Trypanosomatidae, flagellated parasitic protozoa, is responsible for important
infectious diseases in humans: sleeping sickness, Chagas diseases and leishmaniasis …