Sensory neurons with cell bodies situated in dorsal root ganglia convey information from
external or internal sites of the body such as actual or potential harm, temperature or muscle …

Abstract Endothelin-1 (ET-1) is involved in the regulation of a myriad of processes highly
relevant for physical and mental well-being; female and male health; in the modulation of …

Discovered almost 40 years ago, the potent vasoconstrictor peptide endothelin-1 (ET-1) has
a wide range of roles both physiologically and pathologically. In recent years, there has …

The endothelin axis, recognized for its vasoconstrictive action, plays a central role in the
pathology of pulmonary arterial hypertension (PAH). Treatment with approved endothelin …

The dorsal root ganglia (DRG) contain the somas of first-order sensory neurons critical for
somatosensation. Due to technical difficulties, DRG neuronal activity in awake behaving …

To address the global burden of sickle cell disease (SCD) and the need for novel therapies,
the American Society of Hematology partnered with the US Food and Drug Administration to …

Abstract Toll like receptor 7 (TLR7) is expressed in neurons of the dorsal root ganglion
(DRG), but whether it contributes to neuropathic pain is elusive. We found that peripheral …

Sickle cell disease (SCD; ORPHA232; OMIM# 603903) is a chronic and invalidating
disorder distributed worldwide, with high morbidity and mortality. Given the disease …

Endothelin receptor antagonists for the treatment of diabeti... : Current Opinion in Nephrology
and Hypertension Endothelin receptor antagonists for the treatment of diabetic and nondiabetic …

A deeper pathophysiologic understanding of available mouse models of sickle cell disease
(SCD), such as the Townes model, will help improve preclinical studies. We evaluated …