Cerebral malaria is among the major causes of malaria-associated mortality and effective
adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes …

Cerebral malaria (CM) is an acute encephalopathy caused by the malaria parasite
Plasmodium falciparum, which develops in a small minority of infected patients and is …

Necrotizing enterocolitis (NEC) causes acute intestinal necrosis in premature infants and is
associated with severe neurological impairment. In NEC, Toll-like receptor 4 is activated in …

CD4+ T-cells have been shown to play a central role in immune control of infection with
Plasmodium parasites. At the erythrocytic stage of infection, IFN-γ production by CD4+ T …

Interferon gamma (IFN-γ) is a key mediator of inflammatory immune responses induced
primarily by interleukin-12 (IL-12). IFN-γ secretion by both innate and adaptive immune cells …

Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection that
results in thousands of deaths each year, mostly in African children. The in vivo mechanisms …

Cerebral malaria is a devastating complication of Plasmodium falciparum infection. Its
pathogenesis is complex, involving both parasite‐and immune‐mediated events. CD8+ T …

Malaria is one of the most devastating human infectious diseases caused by Plasmodium
spp. parasites. A search for an effective and safe vaccine is the main challenge for its …

In the murine model of cerebral malaria caused by P. berghei ANKA (PbA), parasite-specific
CD8+ T cells directly induce pathology and have long been hypothesized to kill brain …

Natural killer (NK) cells are important innate effector cells that are well described in their
ability to kill virally-infected cells and tumors. However, there is increasing appreciation for …