Near-infrared spectroscopy and skeletal muscle oxidative function in vivo in health and disease: a review from an exercise physiology perspective

B Grassi, V Quaresima - Journal of biomedical optics, 2016 - spiedigitallibrary.org
In most daily activities related to work or leisure, the energy for muscle work substantially
comes from oxidative metabolism. Functional limitations or impairments of this metabolism …

New frontiers in time-domain diffuse optics, a review

A Pifferi, D Contini, AD Mora, A Farina… - … of biomedical optics, 2016 - spiedigitallibrary.org
The recent developments in time-domain diffuse optics that rely on physical concepts (eg,
time-gating and null distance) and advanced photonic components (eg, vertical cavity …

Broadband (600–1350 nm) time-resolved diffuse optical spectrometer for clinical use

SKV Sekar, A Dalla Mora, I Bargigia… - IEEE Journal of …, 2015 - ieeexplore.ieee.org
We report on the design, development, and performance assessment of a portable time-
resolved system measuring absorption and scattering spectra of highly diffusive media over …

Quantification of cerebral blood flow in adults by contrast-enhanced near-infrared spectroscopy: validation against MRI

D Milej, L He, A Abdalmalak… - Journal of Cerebral …, 2020 - journals.sagepub.com
The purpose of this study was to assess the accuracy of absolute cerebral blood flow (CBF)
measurements obtained by dynamic contrast-enhanced (DCE) near-infrared spectroscopy …

[HTML][HTML] Time-resolved single-photon detection module based on silicon photomultiplier: A novel building block for time-correlated measurement systems

E Martinenghi, L Di Sieno, D Contini… - Review of Scientific …, 2016 - pubs.aip.org
We present the design and preliminary characterization of the first detection module based
on Silicon Photomultiplier (SiPM) tailored for single-photon timing applications. The aim of …

Fast silicon photomultiplier improves signal harvesting and reduces complexity in time-domain diffuse optics

AD Mora, E Martinenghi, D Contini, A Tosi, G Boso… - Optics express, 2015 - opg.optica.org
We present a proof of concept prototype of a time-domain diffuse optics probe exploiting a
fast Silicon PhotoMultiplier (SiPM), featuring a timing resolution better than 80 ps, a fast tail …

The SiPM revolution in time-domain diffuse optics

A Dalla Mora, L Di Sieno, A Behera, P Taroni… - Nuclear Instruments and …, 2020 - Elsevier
Time-domain diffuse optics is a powerful non-invasive, non-ionizing and label-free
technique based on the use of picosecond pulsed laser light to probe highly scattering …

Timing measurements with silicon single photon avalanche diodes: principles and perspectives

G Acconcia, F Ceccarelli, A Gulinatti, I Rech - Optics Express, 2023 - opg.optica.org
Picosecond timing of single photons has laid the foundation of a great variety of
applications, from life sciences to quantum communication, thanks to the combination of …

Time-resolved diffuse optical spectroscopy and imaging using solid-state detectors: Characteristics, present status, and research challenges

M Alayed, MJ Deen - Sensors, 2017 - mdpi.com
Diffuse optical spectroscopy (DOS) and diffuse optical imaging (DOI) are emerging non-
invasive imaging modalities that have wide spread potential applications in many fields …

Effects and correctability of pile-up distortion using established figures of merit in time-domain diffuse optics at extreme photon rates

E Avanzi, A Behera, D Contini, L Spinelli… - Scientific reports, 2022 - nature.com
Time-domain diffuse optics (TD-DO) allows one to probe diffusive media with recognized
advantages over other working domains but suffers from a poor signal-to-noise ratio (SNR) …