Among a litany of malignancies affecting the female reproductive tract, that of the ovary is the
most frequently fatal. Moreover, while the steady pace of scientific discovery has fuelled …

Four main histological subtypes of ovarian cancer exist: serous (the most frequent),
endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large …

BRCA1/BRCA2 genes play a central role in DNA repair and their mutations increase
sensitivity to DNA-damaging agents. There are conflicting data regarding the prognostic …

Simple Summary When tumors become resistant to chemotherapeutics, alternative
treatment strategies must be explored. Gene targeting provides a personalized and …

Background In the phase III PAOLA-1 study, the addition of maintenance olaparib to
bevacizumab in patients with newly diagnosed high-grade ovarian cancer (HGOC) resulted …

High-grade serous ovarian cancer (HGSOC) is the most lethal gynecological malignancy. Its
diagnosis at advanced stage compounded with its excessive genomic and cellular …

Abstract Poly-(ADP)-ribose polymerase inhibitors (PARPi) are a class of oral anticancer
drugs first developed as “synthetically lethal” in cancers harboring BRCA1/BRCA2 …

Background: The associations of the consumption of cruciferous vegetables (CVs) and their
bioactive components, isothiocyanates (ITCs), with ovarian cancer (OC) mortality have been …

Mutation or epigenetic silencing of homologous recombination (HR) repair genes is
characteristic of a growing proportion of triple-negative breast cancers (TNBCs) and high …

BRCA1 and BRCA2 are multi-functional proteins and key factors for maintaining genomic
stability through their roles in DNA double strand break repair by homologous …