Effective screening for major aneuploidies can be provided in the first trimester of
pregnancy. Screening by a combination of fetal nuchal translucency and maternal serum …

Objectives To determine the sensitivity and specificity of first‐trimester ultrasound for the
detection of fetal abnormalities and to establish which factors might impact on screening …

Performing a routine first-trimester ultrasound examination at 11+ 0 to 14+ 0 weeks'
gestation is of value for confirming viability and plurality, accurate pregnancy dating …

The current approach to prenatal care, which involves visits at 16, 24, 28, 30, 32, 34 and 36
weeks and then weekly until delivery, was established 80 years ago. The high concentration …

Objective To examine the association between fetal major heart defects and increased
nuchal translucency thickness (NT), tricuspid regurgitation and abnormal flow in the ductus …

Screening for chromosomal disorders, especially for trisomy 21, has undergone a number of
changes in the last 50 years. Today, cell-free DNA analysis (cfDNA) is the gold standard in …

Fetal aneuploidies are among the most common causes of miscarriages, perinatal mortality
and neurodevelopmental impairment. During the last 70 years, many efforts have been …

OBJECTIVE: To estimate the potential value of fetal assessment for tricuspid regurgitation at
11–13 weeks of gestation in the prediction of major cardiac defects. METHODS: We …

Background Down's syndrome occurs when a person has three, rather than two copies of
chromosome 21; or the specific area of chromosome 21 implicated in causing Down's …

Objectives To derive models for estimating risk of miscarriage and stillbirth from maternal
characteristics and findings of first‐trimester screening for aneuploidies and to define the …