Nanomaterial (NM) delivery to solid tumors has been the focus of intense research for over a
decade. Classically, scientists have tried to improve NM delivery by employing passive or …

Nanoparticles have been widely used in tumor targeted drug delivery, while the antitumor
effects are not always satisfactory due to the limited penetration and retention. As we all …

The dense stroma of desmoplastic tumor limits nanotherapeutic penetration and hampers
the antitumor immune response. Here, we report a denaturation-and-penetration strategy …

Nanomedicine has emerged as a promising mean to improve theranostic efficacy and
reduce side effects. Currently, only very small percentage of injected dose reaches the solid …

Over the past few years, the adoption of machine learning (ML) techniques has rapidly
expanded across many fields of research including formulation science. At the same time …

Successfully translating anti-cancer nanomedicines from pre-clinical proof of concept to
demonstration of therapeutic value in the clinic is challenging. Having made significant …

The administration of nanoparticles (NPs) first faces the challenges of evading renal filtration
and clearance of reticuloendothelial system (RES). After that, NPs infiltrate through the …

Despite rapid advancements in the field of nanotechnology, there is mounting frustration in
the scientific community regarding the translational impact of nanomedicine. Modest …

With the development of nanotechnology, significant progress has been made in the design,
and manufacture of nanoparticles (NPs) for use in clinical treatments. Recent increases in …

Introduction Fibroblast activation protein-α (FAPα) is overexpressed on cancer-associated
fibroblasts in approximately 90% of epithelial neoplasms, representing an appealing target …