Measuring biological age using omics data
Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …
related diseases and increase healthspan have suggested targeting the ageing process …
[HTML][HTML] Genetic impacts on DNA methylation: research findings and future perspectives
S Villicaña, JT Bell - Genome biology, 2021 - Springer
Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
Epigenetic-based age acceleration in a representative sample of older Americans: Associations with aging-related morbidity and mortality
Biomarkers developed from DNA methylation (DNAm) data are of growing interest as
predictors of health outcomes and mortality in older populations. However, it is unknown …
predictors of health outcomes and mortality in older populations. However, it is unknown …
A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking
AT Higgins-Chen, KL Thrush, Y Wang, CJ Minteer… - Nature aging, 2022 - nature.com
Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data,
but this data can be surprisingly unreliable. Here we show that technical noise produces …
but this data can be surprisingly unreliable. Here we show that technical noise produces …
Early experiences of threat, but not deprivation, are associated with accelerated biological aging in children and adolescents
Background Recent conceptual models argue that early life adversity (ELA) accelerates
development, which may contribute to poor mental and physical health outcomes. Evidence …
development, which may contribute to poor mental and physical health outcomes. Evidence …
[HTML][HTML] An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray
Genome-wide methylation arrays are powerful tools for assessing cell composition of
complex mixtures. We compare three approaches to select reference libraries for …
complex mixtures. We compare three approaches to select reference libraries for …
[HTML][HTML] A systematic review of childhood maltreatment and DNA methylation: candidate gene and epigenome-wide approaches
Childhood maltreatment is a major risk factor for chronic and severe mental and physical
health problems across the lifespan. Increasing evidence supports the hypothesis that …
health problems across the lifespan. Increasing evidence supports the hypothesis that …
[HTML][HTML] Refining epigenetic prediction of chronological and biological age
Background Epigenetic clocks can track both chronological age (cAge) and biological age
(bAge). The latter is typically defined by physiological biomarkers and risk of adverse health …
(bAge). The latter is typically defined by physiological biomarkers and risk of adverse health …
[HTML][HTML] Systematic evaluation of DNA methylation age estimation with common preprocessing methods and the Infinium MethylationEPIC BeadChip array
Background The capacity of technologies measuring DNA methylation (DNAm) is rapidly
evolving, as are the options for applicable bioinformatics methods. The most commonly used …
evolving, as are the options for applicable bioinformatics methods. The most commonly used …
Integrating DNA methylation measures of biological aging into social determinants of health research
L Raffington, DW Belsky - Current Environmental Health Reports, 2022 - Springer
Abstract Purpose of Review Acceleration of biological processes of aging is hypothesized to
drive excess morbidity and mortality in socially disadvantaged populations. DNA methylation …
drive excess morbidity and mortality in socially disadvantaged populations. DNA methylation …