The size and composition of the CD4+ T-cell population is regulated by balanced
proliferation of progenitor cells and death of mature progeny. After infection with the human …

▪ Abstract In the absence of antiretroviral treatment, HIV-1 establishes a chronic, progressive
infection of the human immune system that invariably, over the course of years, leads to its …

BACKGROUND: Peripheral blood lymphocyte subsets need to be determined in a large,
urban, minority-predominant cohort of healthy children to serve as suitable control subjects …

The thymus is the main producer of αβ T cells and is, therefore, crucial for a normal immune
system. The intrathymic developmental pathway of human αβ T cells has now been …

The human thymus is a complex chimeric organ comprised of central (thymic epithelial
space) and peripheral (perivascular space) components that functions well into adult life to …

Down syndrome (DS) is the most frequent cause of mental retardation in man.
Immunological changes in DS have been observed since the 1970s. The neurological …

The role of the thymus in HIV-1 pathogenesis remains unclear. We developed an assay to
quantify the number of recent thymic emigrants in blood based on the detection of a major …

The incidence of fungal infections in people has increased dramatically over the past 2
decades, as has the number and variety of infecting fungal agents| 1–29]. These trends …

The thymus in adults infected with the HIV-1 is generally thought to be inactive, both
because of age-related involution and viral destruction. We have revisited the question of …

CD8 T cells play an important role in protection and control of HIV-1 by direct cytolysis of
infected cells and by suppression of viral replication by secreted factors. However, although …