Prion diseases are a group of inevitably fatal neurodegenerative disorders affecting
numerous mammalian species, including humans. The existence of heritable phenotypes of …

Numerous proteins are known to form ordered, self-propagating aggregates as underlying
causes of neurodegeneration in proteinopathies such as Alzheimer's, Parkinson's, and prion …

The protein-only hypothesis predicts that infectious mammalian prions are composed solely
of PrPSc, a misfolded conformer of the normal prion protein, PrPC. However, protein-only …

The resolution of the three-dimensional structure of infectious prions at the atomic level is
pivotal to understand the pathobiology of Transmissible Spongiform Encephalopathies …

Understanding the structure of PrPSc is without doubt a sine qua non to understand not only
PrPSc propagation, but also critical features of that process such as the strain phenomenon …

The cellular prion protein, PrP C, is a small, cell surface glycoprotein with a function that is
currently somewhat ill defined. It is also the key molecule involved in the family of …

Saccharomyces cerevisiae is an occasional host to an array of prions, most based on self-
propagating, self-templating amyloid filaments of a normally soluble protein.[URE3] is a …

Prion diseases are neurodegenerative disorders that affect many mammalian species.
Mammalian prion proteins (PrPs) can misfold into many different aggregates. However, only …

The prion-like spreading and accumulation of specific protein aggregates appear to be
central to the pathogenesis of many human diseases, including Alzheimer's and …

The term “prion disease” encompasses a group of neurodegenerative diseases affecting
both humans and animals. Currently, there is no effective therapy and all forms of prion …