Evidence and therapeutic implications of biomechanically regulated immunosurveillance in cancer and other diseases
Disease progression is usually accompanied by changes in the biochemical composition of
cells and tissues and their biophysical properties. For instance, hallmarks of cancer include …
cells and tissues and their biophysical properties. For instance, hallmarks of cancer include …
Mechano-modulation of T cells for cancer immunotherapy
Immunotherapy, despite its promise for future anti-cancer approach, faces significant
challenges, such as off-tumor side effects, innate or acquired resistance, and limited …
challenges, such as off-tumor side effects, innate or acquired resistance, and limited …
POLQ inhibition elicits an immune response in homologous recombination–deficient pancreatic adenocarcinoma via cGAS/STING signaling
G Oh, A Wang, L Wang, J Li, G Werba… - The Journal of …, 2023 - Am Soc Clin Investig
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy that harbors
mutations in homologous recombination–repair (HR-repair) proteins in 20%–25% of cases …
mutations in homologous recombination–repair (HR-repair) proteins in 20%–25% of cases …
[HTML][HTML] Unraveling the potential of 3D bioprinted immunomodulatory materials for regulating macrophage polarization: State-of-the-art in bone and associated tissue …
Macrophage-assisted immunomodulation is an alternative strategy in tissue engineering,
wherein the interplay between pro-inflammatory and anti-inflammatory macrophage cells …
wherein the interplay between pro-inflammatory and anti-inflammatory macrophage cells …
T cells use focal adhesions to pull themselves through confined environments
A Caillier, D Oleksyn, DJ Fowell, J Miller… - Journal of Cell …, 2024 - rupress.org
Immune cells are highly dynamic and able to migrate through environments with diverse
biochemical and mechanical compositions. Their migration has classically been defined as …
biochemical and mechanical compositions. Their migration has classically been defined as …
Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor
J Zhang, J Li, Y Hou, Y Lin, H Zhao, Y Shi, K Chen… - Cell, 2024 - cell.com
Alterations in extracellular matrix (ECM) architecture and stiffness represent hallmarks of
cancer. Whether the biomechanical property of ECM impacts the functionality of tumor …
cancer. Whether the biomechanical property of ECM impacts the functionality of tumor …
LFA-1 regulated by IL-2/STAT5 pathway boosts antitumor function of intratumoral CD8+ T cells for improving anti-PD-1 antibody therapy
J Shan, W Jing, Y Ping, C Shen, D Han, F Liu… - …, 2024 - Taylor & Francis
Anti-PD-1 antibody therapy has achieved success in tumor treatment; however, the duration
of its clinical benefits are typically short. The functional state of intratumoral CD8+ T cells …
of its clinical benefits are typically short. The functional state of intratumoral CD8+ T cells …
Catch bond models may explain how force amplifies TCR signaling and antigen discrimination
The TCR integrates forces in its triggering process upon interaction with pMHC. Force elicits
TCR catch-slip bonds with strong pMHCs but slip-only bonds with weak pMHCs. We …
TCR catch-slip bonds with strong pMHCs but slip-only bonds with weak pMHCs. We …
New insights into CAR T cell-mediated killing of tumor cells
D Espie, E Donnadieu - Frontiers in Immunology, 2022 - frontiersin.org
Adoptive transfer of T cells genetically engineered to express chimeric antigen receptors
(CAR) has demonstrated striking efficacy for the treatment of several hematological …
(CAR) has demonstrated striking efficacy for the treatment of several hematological …
DNA nanotechnology for investigating mechanical signaling in the immune system
Immune recognition occurs at specialized cell‐cell junctions when immune cells and target
cells physically touch. In this junction, groups of receptor‐ligand complexes assemble and …
cells physically touch. In this junction, groups of receptor‐ligand complexes assemble and …