MicroRNA-based diagnosis and therapy

PTB Ho, IM Clark, LTT Le - International journal of molecular sciences, 2022 - mdpi.com
MicroRNAs (miRNAs) are a group of endogenous non-coding RNAs that regulate gene
expression. Alteration in miRNA expression results in changes in the profile of genes …

ncRNA-encoded peptides or proteins and cancer

J Wang, S Zhu, N Meng, Y He, R Lu, GR Yan - Molecular Therapy, 2019 - cell.com
Non-coding RNAs (ncRNAs) are unique RNA transcripts that have been widely identified in
the eukaryotic genome and have been shown to play key roles in the development of many …

[HTML][HTML] TGF-β tumor suppression through a lethal EMT

CJ David, YH Huang, M Chen, J Su, Y Zou, N Bardeesy… - Cell, 2016 - cell.com
TGF-β signaling can be pro-tumorigenic or tumor suppressive. We investigated this duality in
pancreatic ductal adenocarcinoma (PDA), which, with other gastrointestinal cancers …

Regulatory networks defining EMT during cancer initiation and progression

BD Craene, G Berx - Nature Reviews Cancer, 2013 - nature.com
Epithelial to mesenchymal transition (EMT) is essential for driving plasticity during
development, but is an unintentional behaviour of cells during cancer progression. The EMT …

Pancreatic cancer

A Vincent, J Herman, R Schulick, RH Hruban… - The lancet, 2011 - thelancet.com
Substantial progress has been made in our understanding of the biology of pancreatic
cancer, and advances in patients' management have also taken place. Evidence is …

Combined evaluation of a panel of protein and miRNA serum‐exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity

B Madhavan, S Yue, U Galli, S Rana… - … journal of cancer, 2015 - Wiley Online Library
Late diagnosis contributes to pancreatic cancer (PaCa) dismal prognosis, urging for reliable,
early detection. Serum‐exosome protein and/or miRNA markers might be suitable …

Aberrant regulation and function of microRNAs in cancer

BD Adams, AL Kasinski, FJ Slack - Current Biology, 2014 - cell.com
Malignant neoplasms are consistently among the top four leading causes of death in all age
groups in the United States, despite a concerted effort toward developing novel therapeutic …

miR-200–containing extracellular vesicles promote breast cancer cell metastasis

MTN Le, P Hamar, C Guo, E Basar… - The Journal of …, 2014 - Am Soc Clin Investig
Metastasis is associated with poor prognosis in breast cancer patients. Not all cancer cells
within a tumor are capable of metastasizing. The microRNA-200 (miR-200) family, which …

MicroRNAs in body fluids—the mix of hormones and biomarkers

MA Cortez, C Bueso-Ramos, J Ferdin… - Nature reviews Clinical …, 2011 - nature.com
Since the discovery of microRNAs (miRNAs), the study of these small noncoding RNAs has
steadily increased and more than 10,000 papers have already been published. The great …

Epithelial-to-mesenchymal transition: epigenetic reprogramming driving cellular plasticity

N Skrypek, S Goossens, E De Smedt, N Vandamme… - Trends in Genetics, 2017 - cell.com
Epithelial-to-mesenchymal transition (EMT) is a process in which epithelial cells lose their
junctions and polarity to gain a motile mesenchymal phenotype. EMT is essential during …