MicroRNA-based diagnosis and therapy
MicroRNAs (miRNAs) are a group of endogenous non-coding RNAs that regulate gene
expression. Alteration in miRNA expression results in changes in the profile of genes …
expression. Alteration in miRNA expression results in changes in the profile of genes …
ncRNA-encoded peptides or proteins and cancer
J Wang, S Zhu, N Meng, Y He, R Lu, GR Yan - Molecular Therapy, 2019 - cell.com
Non-coding RNAs (ncRNAs) are unique RNA transcripts that have been widely identified in
the eukaryotic genome and have been shown to play key roles in the development of many …
the eukaryotic genome and have been shown to play key roles in the development of many …
[HTML][HTML] TGF-β tumor suppression through a lethal EMT
TGF-β signaling can be pro-tumorigenic or tumor suppressive. We investigated this duality in
pancreatic ductal adenocarcinoma (PDA), which, with other gastrointestinal cancers …
pancreatic ductal adenocarcinoma (PDA), which, with other gastrointestinal cancers …
Regulatory networks defining EMT during cancer initiation and progression
Epithelial to mesenchymal transition (EMT) is essential for driving plasticity during
development, but is an unintentional behaviour of cells during cancer progression. The EMT …
development, but is an unintentional behaviour of cells during cancer progression. The EMT …
Pancreatic cancer
Substantial progress has been made in our understanding of the biology of pancreatic
cancer, and advances in patients' management have also taken place. Evidence is …
cancer, and advances in patients' management have also taken place. Evidence is …
Combined evaluation of a panel of protein and miRNA serum‐exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity
B Madhavan, S Yue, U Galli, S Rana… - … journal of cancer, 2015 - Wiley Online Library
Late diagnosis contributes to pancreatic cancer (PaCa) dismal prognosis, urging for reliable,
early detection. Serum‐exosome protein and/or miRNA markers might be suitable …
early detection. Serum‐exosome protein and/or miRNA markers might be suitable …
Aberrant regulation and function of microRNAs in cancer
Malignant neoplasms are consistently among the top four leading causes of death in all age
groups in the United States, despite a concerted effort toward developing novel therapeutic …
groups in the United States, despite a concerted effort toward developing novel therapeutic …
miR-200–containing extracellular vesicles promote breast cancer cell metastasis
Metastasis is associated with poor prognosis in breast cancer patients. Not all cancer cells
within a tumor are capable of metastasizing. The microRNA-200 (miR-200) family, which …
within a tumor are capable of metastasizing. The microRNA-200 (miR-200) family, which …
MicroRNAs in body fluids—the mix of hormones and biomarkers
MA Cortez, C Bueso-Ramos, J Ferdin… - Nature reviews Clinical …, 2011 - nature.com
Since the discovery of microRNAs (miRNAs), the study of these small noncoding RNAs has
steadily increased and more than 10,000 papers have already been published. The great …
steadily increased and more than 10,000 papers have already been published. The great …
Epithelial-to-mesenchymal transition: epigenetic reprogramming driving cellular plasticity
N Skrypek, S Goossens, E De Smedt, N Vandamme… - Trends in Genetics, 2017 - cell.com
Epithelial-to-mesenchymal transition (EMT) is a process in which epithelial cells lose their
junctions and polarity to gain a motile mesenchymal phenotype. EMT is essential during …
junctions and polarity to gain a motile mesenchymal phenotype. EMT is essential during …