Mitochondria are a distinguishing feature of eukaryotic cells. Best known for their critical
function in energy production via oxidative phosphorylation (OXPHOS), mitochondria are …

Cytochrome c oxidase (CcO) is the terminal oxidase of the mitochondrial electron transport
chain. This bigenomic enzyme in mammals contains 13 subunits of which the 3 catalytic …

Cytochrome c oxidase (COX) from mammals and birds is composed of 13 subunits. The
three catalytic subunits I-III are encoded by mitochondrial DNA, the ten nuclear-coded …

Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and
genetic determinants. We have previously identified iron-responsive element–binding …

Cytochrome c oxidase (COX) deficiency is characterized by a high degree of genetic and
phenotypic heterogeneity, partly reflecting the extreme structural complexity, multiple post …

The lung is a delicate organ with a large surface area that is continuously exposed to the
external environment, and is therefore highly vulnerable to exogenous sources of oxidative …

Mitochondrial biology has seen a surge in popularity in the past 5 years, with the emergence
of numerous new avenues of exciting mitochondria-related research including …

As with other mitochondrial respiratory chain components, marked clinical and genetic
heterogeneity is observed in patients with a cytochrome c oxidase deficiency. This …

Our understanding of stress-associated regulatory mechanisms for mitochondria remains
incomplete. We now report a new regulator of mitochondrial metabolism, the coiled-coil …

Cytochrome c oxidase (COX) is the terminal enzyme of the electron transport chain, made
up of 13 subunits encoded by both mitochondrial and nuclear DNA. Subunit 4 (COX4), a key …