[HTML][HTML] Maternal immune protection against infectious diseases

SN Langel, M Blasi, SR Permar - Cell Host & Microbe, 2022 - cell.com
The maternal immune system protects developing offspring against pathogens before birth
via transplacental transfer and after birth through secreted milk. This transferred maternal …

The conformational states of the HIV-1 envelope glycoproteins

Q Wang, A Finzi, J Sodroski - Trends in microbiology, 2020 - cell.com
During HIV-1 entry into target cells, binding of the virus to host receptors, CD4 and
CCR5/CXCR4, triggers serial conformational changes in the envelope glycoprotein (Env) …

Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques

A Escolano, HB Gristick, ME Abernathy… - Nature, 2019 - nature.com
Broadly neutralizing monoclonal antibodies protect against infection with HIV-1 in animal
models, suggesting that a vaccine that elicits these antibodies would be protective in …

Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection

KO Saunders, RJ Edwards, K Tilahun… - Science translational …, 2022 - science.org
A successful HIV-1 vaccine will require induction of a polyclonal neutralizing antibody (nAb)
response, yet vaccine-mediated induction of such a response in primates remains a …

Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization

M Glögl, N Friedrich, G Cerutti, T Lemmin… - Nature Structural & …, 2023 - nature.com
The third variable (V3) loop on the human immunodeficiency virus 1 (HIV-1) envelope
glycoprotein trimer is indispensable for virus cell entry. Conformational masking of V3 within …

Development of a preventive HIV vaccine requires solving inverse problems which is unattainable by rational vaccine design

MHV Van Regenmortel - Frontiers in immunology, 2018 - frontiersin.org
Hypotheses and theories are essential constituents of the scientific method. Many
vaccinologists are unaware that the problems they try to solve are mostly inverse problems …

Alterations in gp120 glycans or the gp41 fusion peptide-proximal region modulate the stability of the human immunodeficiency virus (HIV-1) envelope glycoprotein …

Z Zhang, Q Wang, HT Nguyen, HC Chen… - Journal of …, 2023 - Am Soc Microbiol
The human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer mediates
entry into host cells by binding receptors, CD4 and CCR5/CXCR4, and fusing the viral and …

Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements

R Henderson, M Lu, Y Zhou, Z Mu, R Parks… - Nature …, 2020 - nature.com
The trimeric HIV-1 Envelope protein (Env) mediates viral-host cell fusion via a network of
conformational transitions, with allosteric elements in each protomer orchestrating host …

Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted/founder sensitivity to broadly neutralizing antibodies

D Parthasarathy, KR Pothula, S Ratnapriya… - Nature …, 2024 - nature.com
Abstract HIV-1 envelope glycoproteins (Envs) of most primary HIV-1 strains exist in closed
conformation and infrequently sample open states, limiting access to internal epitopes. Thus …

Microsecond dynamics control the HIV-1 envelope conformation

AL Bennett, R Edwards, I Kosheleva, C Saunders… - Science …, 2024 - science.org
The HIV-1 Envelope (Env) glycoprotein facilitates host cell fusion through a complex series
of receptor-induced structural changes. Although remarkable progress has been made in …