[HTML][HTML] Maternal immune protection against infectious diseases
The maternal immune system protects developing offspring against pathogens before birth
via transplacental transfer and after birth through secreted milk. This transferred maternal …
via transplacental transfer and after birth through secreted milk. This transferred maternal …
The conformational states of the HIV-1 envelope glycoproteins
During HIV-1 entry into target cells, binding of the virus to host receptors, CD4 and
CCR5/CXCR4, triggers serial conformational changes in the envelope glycoprotein (Env) …
CCR5/CXCR4, triggers serial conformational changes in the envelope glycoprotein (Env) …
Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques
Broadly neutralizing monoclonal antibodies protect against infection with HIV-1 in animal
models, suggesting that a vaccine that elicits these antibodies would be protective in …
models, suggesting that a vaccine that elicits these antibodies would be protective in …
Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection
KO Saunders, RJ Edwards, K Tilahun… - Science translational …, 2022 - science.org
A successful HIV-1 vaccine will require induction of a polyclonal neutralizing antibody (nAb)
response, yet vaccine-mediated induction of such a response in primates remains a …
response, yet vaccine-mediated induction of such a response in primates remains a …
Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization
The third variable (V3) loop on the human immunodeficiency virus 1 (HIV-1) envelope
glycoprotein trimer is indispensable for virus cell entry. Conformational masking of V3 within …
glycoprotein trimer is indispensable for virus cell entry. Conformational masking of V3 within …
Development of a preventive HIV vaccine requires solving inverse problems which is unattainable by rational vaccine design
MHV Van Regenmortel - Frontiers in immunology, 2018 - frontiersin.org
Hypotheses and theories are essential constituents of the scientific method. Many
vaccinologists are unaware that the problems they try to solve are mostly inverse problems …
vaccinologists are unaware that the problems they try to solve are mostly inverse problems …
Alterations in gp120 glycans or the gp41 fusion peptide-proximal region modulate the stability of the human immunodeficiency virus (HIV-1) envelope glycoprotein …
The human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer mediates
entry into host cells by binding receptors, CD4 and CCR5/CXCR4, and fusing the viral and …
entry into host cells by binding receptors, CD4 and CCR5/CXCR4, and fusing the viral and …
Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements
The trimeric HIV-1 Envelope protein (Env) mediates viral-host cell fusion via a network of
conformational transitions, with allosteric elements in each protomer orchestrating host …
conformational transitions, with allosteric elements in each protomer orchestrating host …
Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted/founder sensitivity to broadly neutralizing antibodies
D Parthasarathy, KR Pothula, S Ratnapriya… - Nature …, 2024 - nature.com
Abstract HIV-1 envelope glycoproteins (Envs) of most primary HIV-1 strains exist in closed
conformation and infrequently sample open states, limiting access to internal epitopes. Thus …
conformation and infrequently sample open states, limiting access to internal epitopes. Thus …
Microsecond dynamics control the HIV-1 envelope conformation
AL Bennett, R Edwards, I Kosheleva, C Saunders… - Science …, 2024 - science.org
The HIV-1 Envelope (Env) glycoprotein facilitates host cell fusion through a complex series
of receptor-induced structural changes. Although remarkable progress has been made in …
of receptor-induced structural changes. Although remarkable progress has been made in …