SARS-CoV-2-specific T cells in infection and vaccination

A Bertoletti, N Le Bert, M Qui, AT Tan - Cellular & molecular …, 2021 - nature.com
During viral infections, antibodies and T cells act together to prevent pathogen spread and
remove virus-infected cells. Virus-specific adaptive immunity can, however, also trigger …

Activation or exhaustion of CD8+ T cells in patients with COVID-19

MS Rha, EC Shin - Cellular & molecular immunology, 2021 - nature.com
In addition to CD4+ T cells and neutralizing antibodies, CD8+ T cells contribute to protective
immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID …

SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells

JH Jung, MS Rha, M Sa, HK Choi, JH Jeon… - Nature …, 2021 - nature.com
Memory T cells contribute to rapid viral clearance during re-infection, but the longevity and
differentiation of SARS-CoV-2-specific memory T cells remain unclear. Here we conduct ex …

Does infection with or vaccination against SARS-CoV-2 lead to lasting immunity?

G Milne, T Hames, C Scotton, N Gent… - The Lancet …, 2021 - thelancet.com
Many nations are pursuing the rollout of SARS-CoV-2 vaccines as an exit strategy from
unprecedented COVID-19-related restrictions. However, the success of this strategy relies …

[HTML][HTML] Infection-and vaccine-induced antibody binding and neutralization of the B. 1.351 SARS-CoV-2 variant

VV Edara, C Norwood, K Floyd, L Lai… - Cell host & …, 2021 - cell.com
The emergence of SARS-CoV-2 variants with mutations in the spike protein is raising
concerns about the efficacy of infection-or vaccine-induced antibodies. We compared …

Rapid measurement of SARS-CoV-2 spike T cells in whole blood from vaccinated and naturally infected individuals

AT Tan, JME Lim, N Le Bert… - The Journal of …, 2021 - Am Soc Clin Investig
Defining the correlates of protection necessary to manage the COVID-19 pandemic requires
the analysis of both antibody and T cell parameters, but the complexity of traditional tests …

Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant

F Zuo, H Abolhassani, L Du, A Piralla… - Nature …, 2022 - nature.com
The recent emergence of the Omicron variant has raised concerns on vaccine efficacy and
the urgent need to study more efficient vaccination strategies. Here we observed that an …

T cell response to SARS-CoV-2 infection in humans: A systematic review

M Shrotri, MCI van Schalkwyk, N Post, D Eddy… - PloS one, 2021 - journals.plos.org
Background Understanding the T cell response to SARS-CoV-2 is critical to vaccine
development, epidemiological surveillance and disease control strategies. This systematic …

A scalable serology solution for profiling humoral immune responses to SARS‐CoV‐2 infection and vaccination

K Colwill, Y Galipeau, M Stuible… - Clinical & …, 2022 - Wiley Online Library
Objectives Antibody testing against severe acute respiratory syndrome coronavirus 2 (SARS‐
CoV‐2) has been instrumental in detecting previous exposures and analyzing vaccine …

Public awareness about coronavirus vaccine, vaccine acceptance, and hesitancy

MO Elgendy, MEA Abdelrahim - Journal of medical virology, 2021 - Wiley Online Library
Measurement of the population's general knowledge of the coronavirus vaccine is very
important to improve public acceptance and decrease vaccine hesitancy in confronting the …