To date 15% of couples are suffering from infertility with 45–50% of males being
responsible. With an increase in paternal age as well as various environmental and lifestyle …

Objective High levels of reactive oxygen species (ROS) are intricately linked to obesity and
associated pathologies, notably insulin resistance and type 2 diabetes. However, ROS are …

Ascorbate (AscH−) functions as a versatile reducing agent. At pharmacological doses (P-
AscH−;[plasma AscH−]≥≈ 20 mM), achievable through intravenous delivery, oxidation of P …

The mammalian genome comprises nuclear DNA (nDNA) derived from both parents and
mitochondrial DNA (mtDNA) that is maternally inherited and encodes essential proteins …

Reactive oxygen species (ROS) play important roles in aging, inflammation, and cancer.
Mitochondria are an important source of ROS; however, the spatiotemporal ROS events …

Cellular senescence is a biological process by which cells lose their capacity to proliferate
yet remain metabolically active. Although originally considered a protective mechanism to …

Introduction Despite the widespread use of electronic cigarettes, the long-term health
consequences of vaping are largely unknown. Aims and Methods We investigated the DNA …

The purpose of this study was to determine if mitochondrial dysfunction plays a role in
diabetic nephropathy (DN), a kidney disease which affects> 100 million people worldwide …

Aging is the largest risk factor for cardiovascular disease, yet the molecular mechanisms
underlying vascular aging remain unclear. Mitochondrial DNA (mt DNA) damage is linked to …

DNA lesions and the repair mechanisms that maintain the integrity of genomic DNA are
important in preventing carcinogenesis and its progression. Notably, mutations in DNA …