Role of mitochondria in radiation responses: epigenetic, metabolic, and signaling impacts
D Averbeck, C Rodriguez-Lafrasse - International journal of molecular …, 2021 - mdpi.com
Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …
damage and their management by repair mechanisms. However, molecular biology studies …
Glycosylated porphyrins, phthalocyanines, and other porphyrinoids for diagnostics and therapeutics
S Singh, A Aggarwal, NVSDK Bhupathiraju… - Chemical …, 2015 - ACS Publications
As deaths from preventable diseases abate, cancer is becoming one of the leading causes
of death in the world. Photodynamic therapy (PDT) is a noninvasive treatment for cancer …
of death in the world. Photodynamic therapy (PDT) is a noninvasive treatment for cancer …
Targeting cellular metabolism to improve cancer therapeutics
Y Zhao, EB Butler, M Tan - Cell death & disease, 2013 - nature.com
The metabolic properties of cancer cells diverge significantly from those of normal cells.
Energy production in cancer cells is abnormally dependent on aerobic glycolysis. In addition …
Energy production in cancer cells is abnormally dependent on aerobic glycolysis. In addition …
Role of mitochondrial dysfunction in cancer progression
Deregulated cellular energetics was one of the cancer hallmarks. Several underlying
mechanisms of deregulated cellular energetics are associated with mitochondrial …
mechanisms of deregulated cellular energetics are associated with mitochondrial …
Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction
I Samudio, R Harmancey, M Fiegl… - The Journal of …, 2010 - Am Soc Clin Investig
The traditional view is that cancer cells predominately produce ATP by glycolysis, rather
than by oxidation of energy-providing substrates. Mitochondrial uncoupling—the continuing …
than by oxidation of energy-providing substrates. Mitochondrial uncoupling—the continuing …
Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry
A Hirayama, K Kami, M Sugimoto, M Sugawara, N Toki… - Cancer research, 2009 - AACR
Most cancer cells predominantly produce energy by glycolysis rather than oxidative
phosphorylation via the tricarboxylic acid (TCA) cycle, even in the presence of an adequate …
phosphorylation via the tricarboxylic acid (TCA) cycle, even in the presence of an adequate …
Radiation resistance: a matter of transcription factors
C Galeaz, C Totis, A Bisio - Frontiers in oncology, 2021 - frontiersin.org
Currently, radiation therapy is one of the standard therapies for cancer treatment. Since the
first applications, the field of radiotherapy has constantly improved, both in imaging …
first applications, the field of radiotherapy has constantly improved, both in imaging …
Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond
Tumor cells have an increased demand for nutrients; this demand is met by increased
availability of nutrients through vasculogenesis and by enhanced cellular entry of nutrients …
availability of nutrients through vasculogenesis and by enhanced cellular entry of nutrients …
Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression
Z Chen, Y Li, H Zhang, P Huang, R Luthra - Oncogene, 2010 - nature.com
The mechanisms of compromised mitochondrial function under various pathological
conditions, including hypoxia, remain largely unknown. Recent studies have shown that …
conditions, including hypoxia, remain largely unknown. Recent studies have shown that …
Warburg effect in chemosensitivity: targeting lactate dehydrogenase-A re-sensitizes taxol-resistant cancer cells to taxol
Background Taxol is one of the most effective chemotherapeutic agents for the treatment of
patients with breast cancer. Despite impressive clinical responses initially, the majority of …
patients with breast cancer. Despite impressive clinical responses initially, the majority of …