In humans, various genetic defects or age-related diseases, such as diabetic retinopathies,
glaucoma, and macular degeneration, cause the death of retinal neurons and profound …

Müller glia originate from neuroepithelium and are the principal glial cells in the retina.
During retinal development, Müller glia are one of the last cell types to be born. In lower …

INTRODUCTION The ability to regenerate retinal neurons after injury varies drastically
among vertebrate species. Teleost fish such as zebrafish can regenerate all major retinal …

Human heart failure, a leading cause of death worldwide, is a prominent example of a
chronic disease that may result from poor cell renewal. The Hippo signaling pathway is an …

The development of single-cell RNA sequencing (scRNA-seq) has allowed high-resolution
analysis of cell-type diversity and transcriptional networks controlling cell-fate specification …

Generation of neurons through direct reprogramming has emerged as a promising
therapeutic approach for treating neurodegenerative diseases. In this study, we present an …

In response to retinal damage, the Müller glial cells (MGs) of the zebrafish retina have the
ability to undergo a cellular reprogramming event in which they enter the cell cycle and …

Spiny mice (Acomys cahirinus) are terrestrial mammals that evolved unique scar-free
regenerative wound-healing properties. Myofibroblasts (MFs) are the major scar-forming cell …

Hippo effectors YAP and TAZ control cell fate and survival through various mechanisms,
including transcriptional regulation of key genes. However, much of this research has been …

Background Reprogramming resident glial cells to convert them into neurons in vivo
represents a potential therapeutic strategy that could replenish lost neurons, repair …