[HTML][HTML] Robust T cell response toward spike, membrane, and nucleocapsid SARS-CoV-2 proteins is not associated with recovery in critical COVID-19 patients
CJ Thieme, M Anft, K Paniskaki… - Cell Reports …, 2020 - cell.com
T cell immunity toward SARS-CoV-2 spike (S-), membrane (M-), and nucleocapsid (N-)
proteins may define COVID-19 severity. Therefore, we compare the SARS-CoV-2-reactive T …
proteins may define COVID-19 severity. Therefore, we compare the SARS-CoV-2-reactive T …
Lowest numbers of primary CD8+ T cells can reconstitute protective immunity upon adoptive immunotherapy
C Stemberger, P Graef, M Odendahl… - Blood, The Journal …, 2014 - ashpublications.org
Patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) are
threatened by potentially lethal viral manifestations like cytomegalovirus (CMV) reactivation …
threatened by potentially lethal viral manifestations like cytomegalovirus (CMV) reactivation …
[HTML][HTML] CRISPR-Cas9-edited tacrolimus-resistant antiviral T cells for advanced adoptive immunotherapy in transplant recipients
L Amini, DL Wagner, U Rössler, G Zarrinrad… - Molecular Therapy, 2021 - cell.com
Viral infections, such as with cytomegalovirus (CMV), remain a major risk factor for mortality
and morbidity of transplant recipients because of their requirement for lifelong …
and morbidity of transplant recipients because of their requirement for lifelong …
[HTML][HTML] Tacrolimus-resistant SARS-CoV-2-specific T cell products to prevent and treat severe COVID-19 in immunosuppressed patients
L Peter, DJ Wendering, S Schlickeiser… - … Therapy-Methods & …, 2022 - cell.com
Solid organ transplant (SOT) recipients receive therapeutic immunosuppression that
compromises their immune response to infections and vaccines. For this reason, SOT …
compromises their immune response to infections and vaccines. For this reason, SOT …
Comprehensive approach for identifying the T cell subset origin of CD3 and CD28 antibody–activated chimeric antigen receptor–modified T cells
The outcome of therapy with chimeric Ag receptor (CAR)-modified T cells is strongly
influenced by the subset origin of the infused T cells. However, because polyclonally …
influenced by the subset origin of the infused T cells. However, because polyclonally …
In vitro and in vivo evidence that the switch from calcineurin to mTOR inhibitors may be a strategy for immunosuppression in Epstein–Barr virus–associated post …
CJ Thieme, M Schulz, P Wehler, M Anft, L Amini… - Kidney International, 2022 - Elsevier
Post-transplant lymphoproliferative disorder is a life-threatening complication of
immunosuppression following transplantation mediated by failure of T cells to control …
immunosuppression following transplantation mediated by failure of T cells to control …
Peripheral blood–derived virus-specific memory stem T cells mature to functional effector memory subsets with self-renewal potency
M Schmueck-Henneresse, R Sharaf, K Vogt… - The Journal of …, 2015 - journals.aai.org
Memory T cells expressing stem cell–like properties have been described recently. The
capacity of self-renewal and differentiation into various memory/effector subsets make them …
capacity of self-renewal and differentiation into various memory/effector subsets make them …
The role of CD4+ T cells in BKV-specific T cell immunity
BJD Weist, M Schmueck, H Fuehrer, A Sattler… - Medical microbiology …, 2014 - Springer
Reactivation of polyomavirus BK (BKV) infection represents a severe complication in kidney
transplant (KTX) patients. We previously reported an association between a declining BK …
transplant (KTX) patients. We previously reported an association between a declining BK …
[HTML][HTML] Current advances in experimental and computational approaches to enhance CAR T cell manufacturing protocols and improve clinical efficacy
AS Colina, V Shah, RK Shah, T Kozlik… - Frontiers in Molecular …, 2024 - frontiersin.org
Since the FDA's approval of chimeric antigen receptor (CAR) T cells in 2017, significant
improvements have been made in the design of chimeric antigen receptor constructs and in …
improvements have been made in the design of chimeric antigen receptor constructs and in …
Virus‐specific T‐cell therapy in solid organ transplantation
A Roemhild, P Reinke - Transplant International, 2016 - Wiley Online Library
This article reviews the current state of T‐cell therapy as therapeutic option for virus‐
associated diseases against the background of the most common viral complications and …
associated diseases against the background of the most common viral complications and …