Spinal cord stimulation (SCS) is a minimally invasive therapy used for the treatment of
chronic neuropathic pain. SCS is a safe and effective alternative to medications such as …

The CB1 cannabinoid receptor is a G-protein coupled receptor highly expressed throughout
the central nervous system that is a promising target for the treatment of various disorders …

Various pain therapies have been developed on the basis of the gate control theory of pain,
which postulates that nonpainful sensory inputs mediated by large-diameter afferent fibers …

The discovery of new pain therapeutics targeting human nociceptive circuitry is an
emerging, exciting, and rewarding field. However, current models for evaluating prospective …

Background Traditional spinal cord stimulation (SCS) requires that paresthesia overlaps
chronic painful areas. However, the new paradigm high-frequency SCS (HF-SCS) does not …

Despite the importance of pain as a warning physiological system, chronic neuropathic pain
is frequently caused by damage in the nervous system, followed by persistence over a long …

Electrically activating mechanoreceptive afferents inhibits pain. However, paresthesia
evoked by spinal cord stimulation (SCS) at 40–60 Hz becomes uncomfortable at high pulse …

Abstract Combination tetrahydrocannabinol (THC)/cannabidiol (CBD) medicines or CBD-
only medicines are prospective treatments for chronic pain, stress, anxiety, depression, and …

Spinal cord stimulation (SCS) as an evidence-based interventional treatment has been used
and approved for clinical use in a variety of pathological states including peripheral …

Peripheral nerve stimulation (PNS) is an effective tool for the treatment of chronic pain,
although its efficacy and utilization have previously been significantly limited by technology …