Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes
Lipids are distributed in a highly heterogeneous fashion in different cellular membranes.
Only a minority of lipids achieve their final intracellular distribution through transport by …
Only a minority of lipids achieve their final intracellular distribution through transport by …
Phosphoinositides: tiny lipids with giant impact on cell regulation
T Balla - Physiological reviews, 2013 - journals.physiology.org
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
Endoplasmic reticulum–plasma membrane contact sites
Y Saheki, P De Camilli - Annual review of biochemistry, 2017 - annualreviews.org
The endoplasmic reticulum (ER) has a broad localization throughout the cell and forms
direct physical contacts with all other classes of membranous organelles, including the …
direct physical contacts with all other classes of membranous organelles, including the …
Case–control association mapping by proxy using family history of disease
Collecting cases for case–control genetic association studies can be time-consuming and
expensive. In some situations (such as studies of late-onset or rapidly lethal diseases), it …
expensive. In some situations (such as studies of late-onset or rapidly lethal diseases), it …
Control of metastatic progression by microRNA regulatory networks
N Pencheva, SF Tavazoie - Nature cell biology, 2013 - nature.com
Aberrant microRNA (miRNA) expression is a defining feature of human malignancy. Specific
miRNAs have been identified as promoters or suppressors of metastatic progression …
miRNAs have been identified as promoters or suppressors of metastatic progression …
Phosphatidylinositol-phosphatidic acid exchange by Nir2 at ER-PM contact sites maintains phosphoinositide signaling competence
YJ Kim, ML Guzman-Hernandez, E Wisniewski… - Developmental cell, 2015 - cell.com
Sustained agonist-induced production of the second messengers InsP 3 and diacylglycerol
requires steady delivery of phosphatidylinositol (PtdIns) from its site of synthesis in the ER to …
requires steady delivery of phosphatidylinositol (PtdIns) from its site of synthesis in the ER to …
Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride …
Large-scale meta-analyses of genome-wide association studies (GWAS) have identified>
175 loci associated with fasting cholesterol levels, including total cholesterol (TC), high …
175 loci associated with fasting cholesterol levels, including total cholesterol (TC), high …
CDP-diacylglycerol synthases (CDS): gateway to phosphatidylinositol and cardiolipin synthesis
NJ Blunsom, S Cockcroft - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Cytidine diphosphate diacylglycerol (CDP-DAG) is a key intermediate in the synthesis of
phosphatidylinositol (PI) and cardiolipin (CL). Both PI and CL have highly specialized roles …
phosphatidylinositol (PI) and cardiolipin (CL). Both PI and CL have highly specialized roles …
PITPNC1 recruits RAB1B to the Golgi network to drive malignant secretion
Enhanced secretion of tumorigenic effector proteins is a feature of malignant cells. The
molecular mechanisms underlying this feature are poorly defined. We identify PITPNC1 as a …
molecular mechanisms underlying this feature are poorly defined. We identify PITPNC1 as a …
Phosphatidylinositol 4, 5-bisphosphate homeostasis regulated by Nir2 and Nir3 proteins at endoplasmic reticulum-plasma membrane junctions
Phosphatidylinositol (PI) 4, 5-bisphosphate (PIP 2) at the plasma membrane (PM)
constitutively controls many cellular functions, and its hydrolysis via receptor stimulation …
constitutively controls many cellular functions, and its hydrolysis via receptor stimulation …