RISC assembly: Coordination between small RNAs and Argonaute proteins
H Kobayashi, Y Tomari - Biochimica et Biophysica Acta (BBA)-Gene …, 2016 - Elsevier
Non-coding RNAs generally form ribonucleoprotein (RNP) complexes with their partner
proteins to exert their functions. Small RNAs, including microRNAs, small interfering RNAs …
proteins to exert their functions. Small RNAs, including microRNAs, small interfering RNAs …
Intracellular and extracellular microRNA: An update on localization and biological role
MicroRNA (miRNA) is a class of small non-coding RNAs which mediate post-transcriptional
gene silencing (PTGS) by sequence-specific inhibition of target mRNAs translation and/or …
gene silencing (PTGS) by sequence-specific inhibition of target mRNAs translation and/or …
MicroRNAs as regulators of brain function and targets for treatment of epilepsy
GP Brennan, DC Henshall - Nature Reviews Neurology, 2020 - nature.com
Seizures result from hypersynchronous, abnormal firing of neuronal populations and are the
primary clinical symptom of the epilepsies. Brain tissue from animal models and patients …
primary clinical symptom of the epilepsies. Brain tissue from animal models and patients …
Neuronal extracellular vesicles and associated microRNAs induce circuit connectivity downstream BDNF
A Antoniou, L Auderset, L Kaurani, E Sebastian… - Cell reports, 2023 - cell.com
Extracellular vesicles (EVs) have emerged as mediators of cellular communication, in part
via the delivery of associated microRNAs (miRNAs), small non-coding RNAs that regulate …
via the delivery of associated microRNAs (miRNAs), small non-coding RNAs that regulate …
miR-615-3p promotes the epithelial-mesenchymal transition and metastasis of breast cancer by targeting PICK1/TGFBRI axis
B Lei, D Wang, M Zhang, Y Deng, H Jiang… - Journal of Experimental & …, 2020 - Springer
Background Increasing evidence indicates that epithelial-mesenchymal transition (EMT) can
be regulated by microRNAs (miRNAs). miR-615-3p was shown to be involved in tumor …
be regulated by microRNAs (miRNAs). miR-615-3p was shown to be involved in tumor …
A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking
T Pohlmann, S Baumann, C Haag, M Albrecht… - Elife, 2015 - elifesciences.org
An emerging theme in cellular logistics is the close connection between mRNA and
membrane trafficking. A prominent example is the microtubule-dependent transport of …
membrane trafficking. A prominent example is the microtubule-dependent transport of …
Subcellular heterogeneity of the microRNA machinery
M Trabucchi, R Mategot - Trends in Genetics, 2019 - cell.com
Different methods have recently been developed to understand the subcellular localization
and role of microRNAs (miRNAs) as well as small RNAs associated with Argonaute (AGO) …
and role of microRNAs (miRNAs) as well as small RNAs associated with Argonaute (AGO) …
The coordination of local translation, membranous organelle trafficking, and synaptic plasticity in neurons
Neurons are highly complex polarized cells, displaying an extraordinary degree of spatial
compartmentalization. At presynaptic and postsynaptic sites, far from the cell body, local …
compartmentalization. At presynaptic and postsynaptic sites, far from the cell body, local …
PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 α-appendage and dynamin
M Fiuza, CM Rostosky, GT Parkinson… - Journal of Cell …, 2017 - rupress.org
Clathrin-mediated endocytosis (CME) is used to internalize a diverse range of cargo
proteins from the cell surface, often in response to specific signals. In neurons, the rapid …
proteins from the cell surface, often in response to specific signals. In neurons, the rapid …
mRNA transport meets membrane traffic
Active transport and local translation of mRNAs ensure the appropriate spatial organization
of proteins within cells. Recent work has shown that this process is intricately connected to …
of proteins within cells. Recent work has shown that this process is intricately connected to …