Advances in differential diagnosis and management of growth hormone deficiency in children

C Hage, HW Gan, A Ibba, G Patti, M Dattani… - Nature Reviews …, 2021 - nature.com
Growth hormone (GH) deficiency (GHD) in children is defined as impaired production of GH
by the pituitary gland that results in growth failure. This disease might be congenital or …

Vitamin D and growth hormone in children: a review of the current scientific knowledge

S Esposito, A Leonardi, L Lanciotti, M Cofini… - Journal of Translational …, 2019 - Springer
Background Human growth is a complex mechanism that depends on genetic,
environmental, nutritional and hormonal factors. The main hormone involved in growth at …

An overview of hypoglycemia in children including a comprehensive practical diagnostic flowchart for clinical use

A Casertano, A Rossi, S Fecarotta… - Frontiers in …, 2021 - frontiersin.org
Hypoglycemia is the result of defects/impairment in glucose homeostasis. The main
etiological causes are metabolic and/or endocrine and/or other congenital disorders …

Insights into non-classic and emerging causes of hypopituitarism

F Prodam, M Caputo, C Mele, P Marzullo… - Nature Reviews …, 2021 - nature.com
Hypopituitarism is defined as one or more partial or complete pituitary hormone deficiencies,
which are related to the anterior and/or posterior gland and can have an onset in childhood …

Central adrenal insufficiency in children and adolescents

G Patti, C Guzzeti, N Di Iorgi, AEM Allegri… - Best practice & research …, 2018 - Elsevier
Central adrenal insufficiency (CAI) is a life-threatening condition caused by either pituitary
disease (secondary adrenal insufficiency) or impaired hypothalamic function with …

Contribution of ghrelin to the pathogenesis of growth hormone deficiency

A Lewiński, M Karbownik-Lewińska… - International Journal of …, 2021 - mdpi.com
In this review we described the interactions between ghrelin and the growth hormone (GH)-
insulin-like growth factor 1 (IGF-1) axis in children and adults with growth hormone …

Approach to the pediatric patient: central diabetes insipidus

G Patti, F Napoli, D Fava, E Casalini… - The Journal of …, 2022 - academic.oup.com
Central diabetes insipidus (CDI) is a complex disorder in which large volumes of dilute urine
are excreted due to arginine-vasopressin deficiency, and it is caused by a variety of …

Extending lifespan by modulating the growth hormone/insulin-like growth factor-1 axis: coming of age

S Duran-Ortiz, EO List, R Basu, JJ Kopchick - Pituitary, 2021 - Springer
Progress made in the years of aging research have allowed the opportunity to explore
potential interventions to slow aging and extend healthy lifespan. Studies performed in …

Congenital hypopituitarism

JS Parks - Clinics in Perinatology, 2018 - perinatology.theclinics.com
Timely recognition of severe, congenital hypopituitarism is challenging. Short stature does
not force consideration of the diagnosis, because birth weight and length are typically …

Diagnosis and Incidence of Congenital Combined Pituitary Hormone Deficiency in Denmark—A National Observational Study

LK Jakobsen, RB Jensen, NH Birkebæk… - The Journal of …, 2023 - academic.oup.com
Context Congenital combined pituitary hormone deficiency (cCPHD) is the loss of≥ 2
pituitary hormones caused by congenital factors. Objective We aimed to estimate the …