This review presents the biological activity—antibacterial, antifungal, anti-parasitic, antiviral,
antitumor, antiinflammatory, antioxidant, and enzymatic activity—of halogenated marine …

Covering: 31st December 2004Natural product and natural product-derived compounds that
are being evaluated in clinical trials or in registration (current 31 December 2004) have …

Pain therapeutics discovered by molecular mining of the expressed genome of Australian
predatory cone snails are providing lead compounds for the treatment of neurological …

G protein-coupled receptors (GPCRs) are considered to represent the most promising drug
targets; it has been repeatedly said that a large fraction of the currently marketed drugs elicit …

The complex mixture of biologically active peptides that constitute the venom of Conus
species provides a rich source of ion channel neurotoxins. These peptides, commonly …

A benzothiazole-derived compound (4a) designed to mimic the Cα–Cβ bond vectors and
terminal functionalities of Lys2, Tyr13 and Arg17 in ω-conotoxin GVIA was synthesised …

Peptide toxins typically bind to their target ion channels or receptors with high potency and
selectivity, making them attractive leads for therapeutic development. In some cases the …

US7538190B2 - Methods for the synthesis of two or more dicarba bridges in organic
compounds - Google Patents US7538190B2 - Methods for the synthesis of two or more dicarba …

US7745573B2 - Conotoxin analogues and methods for synthesis of intramolecular dicarba
bridge-containing peptides - Google Patents US7745573B2 - Conotoxin analogues and …

α-Conotoxins are peptide neurotoxins isolated from venomous marine cone snails that are
potent and selective antagonists for different subtypes of nicotinic acetylcholine receptors …