Conditioned place preference (CPP) continues to be one of the most popular models to
study the motivational effects of drugs and non‐drug treatments in experimental animals …

Muscarinic acetylcholine receptors (mAChRs), M1–M5, regulate the activity of numerous
fundamental central and peripheral functions. The lack of small-molecule ligands that can …

A spirited and thought-provoking history of the vast changes that transformed Europe during
the 1,000-year span of the Middle Ages The millennium between the breakup of the western …

Muscarinic acetylcholine receptors (mAChRs; M1–M5) play key roles in regulating the
activity of many important functions of the central and peripheral nervous system. Because of …

Muscarinic and nicotinic acetylcholine (ACh) receptors (mAChRs and nAChRs) are
emerging as important targets for the development of novel treatments for the symptoms …

Striatal cholinergic interneurons (ChIs) are central for the processing and reinforcement of
reward‐related behaviors that are negatively affected in states of altered dopamine …

Dopaminergic neurons in the substantia nigra pars compacta and ventral tegmental area of
the midbrain form the nigrostriatal and mesocorticolimbic dopaminergic pathways that …

The degeneration of cholinergic neurons and cholinergic hypofunction are pathologies
associated with Alzheimer's disease (AD). Muscarinic acetylcholine receptors (mAChRs) …

Central nervous system cholinergic neurons arise from several discrete sources, project to
multiple brain regions, and exert specific effects on reward, learning, and memory. These …

Statistical and machine learning approaches predict drug-to-target relationships from 2D
small-molecule topology patterns. One might expect 3D information to improve these …