Liver resection causes marked perfusion alterations in the liver remnant both on the organ
scale (vascular anatomy) and on the microscale (sinusoidal blood flow on tissue level) …

The KDEL receptor retrieval pathway is essential for maintaining resident proteins in the
endoplasmic reticulum (ER) lumen. ER resident proteins serve a variety of functions …

The adult liver has an exceptional ability to regenerate, but how it maintains its specialized
functions during regeneration is unclear. Here, we used partial hepatectomy (PHx) in …

Animal studies are required for the evaluation of candidate drugs to ensure patient and
volunteer safety. Toxicogenomics is often applied in these studies to gain understanding of …

Ideal therapies for regenerative medicine or healthy aging require healthy organ growth and
rejuvenation, but no organ-level approach is currently available. Using Mycobacterium …

The regenerative capabilities of the liver represent a paradigm for understanding tissue
repair in solid organs. Regeneration after partial hepatectomy in rodent models is well …

Background & Aims Although extensive experimental evidence on the process of liver
regeneration exists, in humans, validation is largely missing. However, liver regeneration is …

Liver regeneration is characterized by cell cycle reentrance of hepatocytes. N-Myc, encoded
by MYCN, is a member of the Myc family of transcription factors. Elevation of MYCN …

Simple Summary DNA repair pathways have been implicated in hepatocellular carcinoma
outcomes. We found that hepatocellular carcinomas (HCC) could be separated into two …

Background: Lung cancer is the second most common cancer and the main leading cause
of cancer-associated death worldwide. Non-small cell lung cancer (NSCLC) accounts for …