The synthesis of pyrrolidine compounds with biological interest is an active research topic.
Glycine could be a versatile starting material for making pyrrolidine derivatives. This review …

In this review, we evaluated the biological activities of hybrid molecules incorporating
imidazoles—a cornerstone in medicinal chemistry known for their broad pharmacological …

The Zn (II)/UCD-Imphanol-catalyzed highly endo-selective [3+ 2] asymmetric cycloaddition
of acyclic enones and azomethine ylides has been developed. Moderate to high yields (up …

An intramolecular 1, 2-amidooxygenation of unactivated alkenes for the construction of the
pyrrolidinone scaffold containing a masked 5-hydroxymethyl functionality is reported. γ, δ …

We describe the single-step formation of complex tetracyclic fused scaffolds enabled by (3+
2) cycloaddition of azomethine ylides. Various indoles, N-protecting groups, and amino …

In this work, the tricyclic fused host systems N, N′-bis (9-phenyl-9 H-xanthen-9-yl) butane-
1, 4-diamine (H1) and N, N′-bis (9-(naphthalen-1-yl)-9 H-xanthen-9-yl) butane-1, 4 …

Dearomative 1, 3-dipolar cycloadditions of 1-Boc-pyrroles with in situ generated silver α-
bromo alkylidenenitronates delivered a series of 3a, 6a-dihydro-4-Boc-pyrrolo [2, 3-d] …

Introduction: Pharmacotherapeutic targets for breast cancer include the estrogen receptor
(ER), progesterone receptor (PR), and human epidermal growth factor receptor (EGFR) …

Convenient synthesis of stereochemically dense 5-oxo-pyrrolidines was obtained from
succinic anyhdride and imines by combining the Castagnoli–Cushman reaction with …

A method for the construction of trifluorinated-5-methylenepyrrolidinone is reported. This
strategy combines an acid-catalyzed two-carbon homologation process between ynamides …