This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Cardiovascular disease is a leading cause of death worldwide and accounts for> 17.3
million deaths per year, with an estimated increase in incidence to 23.6 million by 2030 …

This e-book will review special features of the cerebral circulation and how they contribute to
the physiology of the brain. It describes structural and functional properties of the cerebral …

The L-type Cav1. 2 calcium channel is present throughout the animal kingdom and is
essential for some aspects of CNS function, cardiac and smooth muscle contractility …

Abstract Development of a vascularized tissue is one of the key challenges for the
successful clinical application of tissue engineered constructs. Despite the significant efforts …

Current knowledge about the molecular mechanisms of NMDA receptor (NMDAR)-
independent long-term potentiation (LTP) in the hippocampus and its function for memory …

Voltage-gated calcium channels (VGCCs) comprise five subtypes: The L‑type; R‑type; N‑
type; P/Q‑type; and T‑type, which are encoded by α1 subunit genes. Calcium ion channels …

Despite the central physiological function of the myogenic response, the underlying
signalling pathways and the identity of mechanosensors in vascular smooth muscle (VSM) …