Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of
cancer, from tumour initiation through disease progression and therapy resistance, requires …

As cancer cells develop resistance to apoptosis, non-apoptotic cell death modalities, such
as ferroptosis, have emerged as promising strategies to combat therapy-resistant cancers …

Pyroptosis, as a novel mode of cell death, has been proven to have impressive antitumor
effects. Dying cells undergoing pyroptosis can elicit antitumor immunity by the release of …

Deregulation of tumor cell metabolism is widely recognized as a “hallmark of cancer.” Many
of the selective pressures encountered by tumor cells, such as exposure to anticancer …

Lipids, as one of the three primary energy sources, provide energy for all cellular life
activities. Lipids are also known to be involved in the formation of cell membranes and play …

Simple Summary ACSL4 is an enzyme involved in the intracellular conversion of long-chain
fatty acids and coenzyme A into fatty-acid coenzymes. It plays a vital role in various …

Cisplatin resistance along with chemotherapy-induced neuropathic pain is an important
cause of treatment failure for many cancer types and represents an unmet clinical need …

Simple Summary Mitochondria, often called “the powerhouse of the cell”, generate most of
the energy required for all cellular processes. Mitochondria also provide a platform for …

The immune function of normal T cells partially depends on the maneuvering of lipid
metabolism through various stages and subsets. Interestingly, T-cell malignancies also …

Tamoxifen-based endocrine therapy remains a major adjuvant therapy for estrogen receptor
(ER)-positive breast cancer (BC). However, many patients develop tamoxifen resistance …