[HTML][HTML] Retinoic acid, CYP26, and drug resistance in the stem cell niche
Highlights•The bone marrow microenvironment metabolizes retinoids via CYP26 and
creates low-retinoid niches.•Normal hematopoietic stem cells (HSCs) are protected in these …
creates low-retinoid niches.•Normal hematopoietic stem cells (HSCs) are protected in these …
Hedgehog and retinoid signaling alters multiple myeloma microenvironment and generates bortezomib resistance
S Alonso, D Hernandez, Y Chang… - The Journal of …, 2017 - Am Soc Clin Investig
Interactions between multiple myeloma (MM) cells and the BM microenvironment play a
critical role in bortezomib (BTZ) resistance. However, the mechanisms involved in these …
critical role in bortezomib (BTZ) resistance. However, the mechanisms involved in these …
Potential Role for All-trans Retinoic Acid in Nonpromyelocytic Acute Myeloid Leukemia
HS Ma, TM Robinson, D Small - International Journal of …, 2016 - Taylor & Francis
All-trans retinoic acid (ATRA) has been very successful in the subtype of acute myelogenous
leukemia known as acute promyelocytic leukemia due to targeted reactivation of retinoic …
leukemia known as acute promyelocytic leukemia due to targeted reactivation of retinoic …