Over the past two decades, synergistic innovations in imaging technology have resulted in a
revolution in which a range of biomedical applications are now benefiting from fluorescence …

Background: Alkylphospholipids (APLs) are synthetically derived from cell membrane
components, which they target and thus modify cellular signalling and cause diverse effects …

BACKGROUND: 5-Aminolevulinic acid (5-ALA)-induced tumor fluorescence aids brain
tumor resections but is not approved for routine use in the United States. We developed and …

Background Systemic radiation treatments that preferentially irradiate cancer cells over
normal tissue, known as targeted radionuclide therapy (TRT), have shown significant …

Cancer-targeting alkylphosphocholine (APC) analogues are being clinically developed for
diagnostic imaging, intraoperative visualization, and therapeutic applications. These APC …

Cancer is the second leading cause of death for children between the ages of 5 and 14 y.
For children diagnosed with metastatic or recurrent solid tumors, for which the utility of …

Methods 6-week-old male FVB mice were implanted subcutaneously with Myc-CaP tumor
cells and given a single intravenous injection of 90 Y-NM600, in combination with ADT …

Objectives In an effort to exploit the elevated need for phospholipids displayed by cancer
cells relative to normal cells, we have developed tumor-targeted alkylphosphocholines …

Purpose: Auger electrons emitted by radioisotopes such as 125I have a high linear energy
transfer and short mean-free path in tissue (< 10 μm), making them suitable for treating …

There is a growing need to estimate the absorbed dose to small animals from preclinical
investigations involving diagnostic and therapeutic radiopharmaceuticals. This paper …