The native chemical ligation reaction (NCL) involves reacting a C-terminal peptide thioester
with an N-terminal cysteinyl peptide to produce a native peptide bond between the two …

The present review offers an overview of nonclassical (eg, with no pre-or in situ activation of
a carboxylic acid partner) approaches for the construction of amide bonds. The review aims …

Methods to prepare proteins that include a specific modification at a desired position are
essential for understanding their cellular functions and physical properties in living systems …

Contemporary chemical protein synthesis has been dramatically advanced over the past few
decades, which has enabled chemists to reach the landscape of synthetic …

An operationally simple method for the synthesis of peptide thioesters is developed using
standard Fmoc solid-phase peptide synthesis procedures. The method relies on the use of a …

Since the 1990s, α-oxo aldehyde or glyoxylic acid chemistry has inspired a vast array of
synthetic tools for tailoring peptide or protein structures, for developing peptides endowed …

Small ubiquitin-like modifier (SUMO) post-translational modification (PTM) of proteins has a
crucial role in the regulation of important cellular processes. This protocol describes the …

The chemical synthesis of peptides or small proteins is often an important step in many
research projects and has stimulated the development of numerous chemical …

A variety of methods have been employed to study the impact of posttranslational
modifications on Tau protein function. Here, a semisynthesis strategy is described that …

Peptide–drug conjugates (PDCs) have recently emerged as interesting hybrid constructs not
only for targeted therapy, but also for the early diagnosis of different pathologies. In most …