Therapeutically harnessing extracellular vesicles
The field of extracellular vesicle (EV) research has developed rapidly over the last decade
from the study of fundamental biology to a subject of significant clinical relevance. The …
from the study of fundamental biology to a subject of significant clinical relevance. The …
Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?
M Kou, L Huang, J Yang, Z Chiang, S Chen, J Liu… - Cell Death & …, 2022 - nature.com
Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone
marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and …
marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and …
A paradigm shift in cell-free approach: the emerging role of MSCs-derived exosomes in regenerative medicine
S Moghadasi, M Elveny, HS Rahman… - Journal of translational …, 2021 - Springer
Recently, mesenchymal stem/stromal cells (MSCs) due to their pro-angiogenic, anti-
apoptotic, and immunoregulatory competencies along with fewer ethical issues are …
apoptotic, and immunoregulatory competencies along with fewer ethical issues are …
Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer
Z Weng, B Zhang, C Wu, F Yu, B Han, B Li… - Journal of hematology & …, 2021 - Springer
Extracellular vesicles (EVs) are cell-derived membrane structures enclosing proteins, lipids,
RNAs, metabolites, growth factors, and cytokines. EVs have emerged as essential …
RNAs, metabolites, growth factors, and cytokines. EVs have emerged as essential …
[HTML][HTML] Dosing extracellular vesicles
D Gupta, AM Zickler, S El Andaloussi - Advanced drug delivery reviews, 2021 - Elsevier
Extracellular vesicles (EVs) are natural nanoparticles containing biologically active
molecules. They are important mediators of intercellular communication and can be …
molecules. They are important mediators of intercellular communication and can be …
Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials
A Lotfy, NM AboQuella, H Wang - Stem Cell Research & Therapy, 2023 - Springer
Mesenchymal stromal/stem cells (MSCs) are widely utilized in cell therapy because of their
robust immunomodulatory and regenerative properties. Their paracrine activity is one of the …
robust immunomodulatory and regenerative properties. Their paracrine activity is one of the …
Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine
Mesenchymal stem cells (MSCs) have captured great attention in regenerative medicine for
over a few decades by virtue of their differentiation capacity, potent immunomodulatory …
over a few decades by virtue of their differentiation capacity, potent immunomodulatory …
Review of the isolation, characterization, biological function, and multifarious therapeutic approaches of exosomes
Exosomes are extracellular vesicles that contain a specific composition of proteins, lipids,
RNA, and DNA. They are derived from endocytic membranes and can transfer signals to …
RNA, and DNA. They are derived from endocytic membranes and can transfer signals to …
Mesenchymal stem/stromal cell-derived exosomes for immunomodulatory therapeutics and skin regeneration
DH Ha, H Kim, J Lee, HH Kwon, GH Park, SH Yang… - Cells, 2020 - mdpi.com
Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication.
With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the …
With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the …
Cell-derived nanovesicle-mediated drug delivery to the brain: principles and strategies for vesicle engineering
Y Liang, Z Iqbal, J Lu, J Wang, H Zhang, X Chen… - Molecular Therapy, 2023 - cell.com
Developing strategies toward safe and effective drug delivery into the central nervous
system (CNS) with improved targeting abilities and reduced off-target effects is crucial. CNS …
system (CNS) with improved targeting abilities and reduced off-target effects is crucial. CNS …