Histone deacetylases (HDACs) are essential for maintaining homeostasis by catalyzing
histone deacetylation. Aberrant expression of HDACs is associated with various human …

Harmonious synthesis and distribution of melanin in the skin contribute to the expression of
beauty and the maintenance of health. When skin pigmentary disorders occur because of …

Hirsutanone (Hir) and oregonin (Ore) are diarylheptanoids isolated from the bark of Alnus
japonica. In this study, we investigated the anti-melanogenic activity of Hir and Ore in B16 …

A series of new hybrid derivatives 1a–c, 2a–c, 3a–c, 4a–c, 5a–c, inspired by nature, were
synthesized and studied as multifunctional agents for the treatment of Alzheimer's disease …

CMT-308 is a nonantimicrobial chemically-modified tetracycline (CMT), which we have
previously shown exhibits antifungal activity and pleiotropic anti-inflammatory activities …

Skin hypopigmentation, which is observed in albinism or vitiligo, occurs when melanin
synthesis is decreased by genetic, epigenetic, and other factors. To identify drug candidates …