For decades after the discovery that a contractile ring made of actin filaments and myosin II
produces the force to constrict the cleavage furrow of animal cells, the complexity of …

Anillin is a highly conserved multidomain protein that interacts with cytoskeletal components
as well as their regulators. Throughout phylogeny, Anillins contribute to cytokinesis, the cell …

The contractile ring is essential for cytokinesis in most fungal and animal cells. In fission
yeast, cytokinesis nodes are precursors of the contractile ring and mark the future cleavage …

CDC14 was originally identified by L. Hartwell in his famous screen for genes that regulate
the budding yeast cell cycle. Subsequent work showed that Cdc14 belongs to a family of …

Simple Summary Cancer is increasingly viewed as a cell cycle disease in that the
dysregulation of the cell cycle machinery is a common feature in cancer. The Hippo …

The contractile ring is a complex molecular apparatus which physically divides many
eukaryotic cells. Despite knowledge of its protein composition, the molecular architecture of …

How the actin cytoskeleton assembles into different structures to drive diverse cellular
processes is a fundamental cell biological question. In addition to orchestrating the …

Cytokinesis in Schizosaccharomyces pombe requires the function of Cdc15, the founding
member of the pombe cdc15 homology (PCH) family of proteins. As an early, abundant …

In both animal cells and fungi, cytokinesis proceeds via a contractile actomyosin ring (CAR).
Many CAR components and regulators are evolutionarily conserved. In …

Cdc15p is known to contribute to cytokinesis in fission yeast; however, the protein is not
required to assemble the contractile ring of actin and myosin, but it helps to anchor the ring …