Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells
to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in …

Reduced glutathione (GSH) is the most prevalent non-protein thiol in animal cells. Its de
novo and salvage synthesis serves to maintain a reduced cellular environment and the …

BACKGROUND: The cytosolic glutathione transferases (GSTs) comprise a super family of
proteins that can be categorized into multiple classes with a mixture of highly specific and …

The immune and the detoxication systems of animals are characterized by allelic
polymorphisms, which underlie individual differences in ability to combat assaults from …

ContextLittle is known about genetic susceptibility to cigarette smoke in relation to adverse
pregnancy outcomes. ObjectiveTo investigate whether the association between maternal …

Glutathione S-transferases (GSTs) are an important part of the cellular detoxification system
and, perhaps, evolved to protect cells against reactive oxygen metabolites. Theta is …

Context Continuing advances in genotyping technologies and the inclusion of DNA
collection in observational studies have resulted in an increasing number of genetic …

A deletion polymorphism in glutathione S-transferase theta (GSTT1) gene was recently
discovered in humans. Similar to the GSTM1 gene, GSTT1 is also recognized as a risk …

Although cytosolic glutathione S-transferase (GST) enzymes occupy a key position in
biological detoxification processes, two of the most relevant human isoenzymes, GSTT1-1 …

This review focuses on genes other than the high penetrance genes BRCA1 and BRCA2
that are involved in breast cancer susceptibility. The goal of this review is the discovery of …