G-protein-coupled receptors (GPCRs) have been tractable drug targets for decades with
over one-third of currently marketed drugs targeting GPCRs. Of these, the class A GPCR …

G protein–coupled receptors (GPCRs) are integral membrane proteins that represent an
important class of drug targets. In particular, aminergic GPCRs interact with a significant …

Allosteric modulation of G protein-coupled receptors (GPCRs) is nowadays a hot topic in
medicinal chemistry. Allosteric modulators, ie, compounds which bind in a receptor site …

Allosteric modulators (AMs) of G-protein coupled receptors (GPCRs) are desirable drug
targets because they can produce fewer on-target side effects, improved selectivity, and …

The hydroxyproline-rich glycoproteins (HRGPs) are the major structural proteins of the
extracellular matrix of algae and land plants. They are characterized by a rigid polyproline …

A new non-natural β-amino acid, named 3-Ar-β-Morph, was designed and synthesized via a
regio-and diastereoselective Pd-catalyzed C (sp3) H-arylation of the corresponding 2 S, 6 S …

Parkinson&aposs disease (PD) is t he second most common form of neurodegenerative
disorders that results from the progressive loss of dopaminergic neurons in the midbrain …

Disclosed are compounds having enhanced potency in the modulation of NMD A receptor
activity. Such compounds are contemplated for use in the treatment of conditions such as …

7, 273, 889 B2 9/2007 Mermelstein et al. 7, 884, 080 B2 2/2011 Aslanian et al. 8, 492, 340
B2 7/2013 Moskal 2002/0103335 A1 8/2002 Oldham et al. 2003/0022253 A1 1/2003 Moskal …

Disclosed are compounds having enhanced potency in the modulation of NMDA receptor
activity. Such compounds are contemplated for use in the treatment of conditions such as …