[HTML][HTML] A systematic review of computational approaches to understand cancer biology for informed drug repurposing
F Ahmed, A Samantasinghar, AM Soomro, S Kim… - Journal of Biomedical …, 2023 - Elsevier
Cancer is the second leading cause of death globally, trailing only heart disease. In the
United States alone, 1.9 million new cancer cases and 609,360 deaths were recorded for …
United States alone, 1.9 million new cancer cases and 609,360 deaths were recorded for …
[HTML][HTML] Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer
We conducted comprehensive integrative molecular analyses of the complete set of tumors
in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and …
in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and …
The chromatin accessibility landscape of primary human cancers
INTRODUCTION Cancer is one of the leading causes of death worldwide. Although the 2%
of the human genome that encodes proteins has been extensively studied, much remains to …
of the human genome that encodes proteins has been extensively studied, much remains to …
Clinical and genomic characterization of treatment-emergent small-cell neuroendocrine prostate cancer: a multi-institutional prospective study
Purpose The prevalence and features of treatment-emergent small-cell neuroendocrine
prostate cancer (t-SCNC) are not well characterized in the era of modern androgen receptor …
prostate cancer (t-SCNC) are not well characterized in the era of modern androgen receptor …
Deep learning of pharmacogenomics resources: moving towards precision oncology
The recent accumulation of cancer genomic data provides an opportunity to understand how
a tumor's genomic characteristics can affect its responses to drugs. This field, called …
a tumor's genomic characteristics can affect its responses to drugs. This field, called …
The UCSC Xena platform for public and private cancer genomics data visualization and interpretation
M Goldman, B Craft, M Hastie, K Repečka, F McDade… - biorxiv, 2018 - biorxiv.org
UCSC Xena is a visual exploration resource for both public and private omics data,
supported through the web-based Xena Browser and multiple turn-key Xena Hubs. This …
supported through the web-based Xena Browser and multiple turn-key Xena Hubs. This …
Integrated molecular characterization of testicular germ cell tumors
We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensional assays
of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited …
of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited …
[HTML][HTML] Genomic, pathway network, and immunologic features distinguishing squamous carcinomas
JD Campbell, C Yau, R Bowlby, Y Liu, K Brennan… - Cell reports, 2018 - cell.com
Summary This integrated, multiplatform PanCancer Atlas study co-mapped and identified
distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites …
distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites …
Predicting drug response of tumors from integrated genomic profiles by deep neural networks
Background The study of high-throughput genomic profiles from a pharmacogenomics
viewpoint has provided unprecedented insights into the oncogenic features modulating drug …
viewpoint has provided unprecedented insights into the oncogenic features modulating drug …
Integrated genomic profiling expands clinical options for patients with cancer
Genomic analysis of paired tumor–normal samples and clinical data can be used to match
patients to cancer therapies or clinical trials. We analyzed 500 patient samples across …
patients to cancer therapies or clinical trials. We analyzed 500 patient samples across …