Metabolic engineering: methodologies and applications
Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …
through the genetic manipulation of microbial metabolism. While the discipline is a little over …
Review of recent developments in GC–MS approaches to metabolomics-based research
Background Metabolomics aims to identify the changes in endogenous metabolites of
biological systems in response to intrinsic and extrinsic factors. This is accomplished …
biological systems in response to intrinsic and extrinsic factors. This is accomplished …
MetaboAnalyst 2.0—a comprehensive server for metabolomic data analysis
First released in 2009, MetaboAnalyst (www. metaboanalyst. ca) was a relatively simple web
server designed to facilitate metabolomic data processing and statistical analysis. With …
server designed to facilitate metabolomic data processing and statistical analysis. With …
[HTML][HTML] Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst
J Xia, DS Wishart - Nature protocols, 2011 - nature.com
MetaboAnalyst is an integrated web-based platform for comprehensive analysis of
quantitative metabolomic data. It is designed to be used by biologists (with little or no …
quantitative metabolomic data. It is designed to be used by biologists (with little or no …
The moderately efficient enzyme: evolutionary and physicochemical trends shaping enzyme parameters
The kinetic parameters of enzymes are key to understanding the rate and specificity of most
biological processes. Although specific trends are frequently studied for individual enzymes …
biological processes. Although specific trends are frequently studied for individual enzymes …
MSEA: a web-based tool to identify biologically meaningful patterns in quantitative metabolomic data
J Xia, DS Wishart - Nucleic acids research, 2010 - academic.oup.com
Gene set enrichment analysis (GSEA) is a widely used technique in transcriptomic data
analysis that uses a database of predefined gene sets to rank lists of genes from microarray …
analysis that uses a database of predefined gene sets to rank lists of genes from microarray …
[HTML][HTML] Analytical platform for metabolome analysis of microbial cells using methyl chloroformate derivatization followed by gas chromatography–mass spectrometry
KF Smart, RBM Aggio, JR Van Houtte… - Nature protocols, 2010 - nature.com
This protocol describes an analytical platform for the analysis of intra-and extracellular
metabolites of microbial cells (yeast, filamentous fungi and bacteria) using gas …
metabolites of microbial cells (yeast, filamentous fungi and bacteria) using gas …
High-throughput, accurate mass metabolome profiling of cellular extracts by flow injection–time-of-flight mass spectrometry
Direct injection of samples on high-resolving mass spectrometers is an effective way to
maximize analytical throughput and yet allow analyte discrimination in complex samples by …
maximize analytical throughput and yet allow analyte discrimination in complex samples by …
Current metabolomics: practical applications
The field of metabolomics continues to grow rapidly over the last decade and has been
proven to be a powerful technology in predicting and explaining complex phenotypes in …
proven to be a powerful technology in predicting and explaining complex phenotypes in …
Ultrahigh performance liquid chromatography− tandem mass spectrometry method for fast and robust quantification of anionic and aromatic metabolites
Quantification of metabolites is of pivotal relevance in biology, where it complements more
established omics techniques such as transcriptomics and proteomics. Here, we present a …
established omics techniques such as transcriptomics and proteomics. Here, we present a …