Personalized vaccines for cancer immunotherapy

U Sahin, Ö Türeci - Science, 2018 - science.org
Cancer is characterized by an accumulation of genetic alterations. Somatic mutations can
generate cancer-specific neoepitopes that are recognized by autologous T cells as foreign …

Dendritic cell immunotherapy: mapping the way

CG Figdor, IJM de Vries, WJ Lesterhuis, CJM Melief - Nature medicine, 2004 - nature.com
Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system,
with the potential to either stimulate or inhibit immune responses. Exploiting the immune …

Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial

B Escudier, T Dorval, N Chaput, F André… - Journal of translational …, 2005 - Springer
Background DC derived-exosomes are nanomeric vesicles harboring functional
MHC/peptide complexes capable of promoting T cell immune responses and tumor …

Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids

V Wittamer, JD Franssen, M Vulcano… - The Journal of …, 2003 - rupress.org
Dendritic cells (DCs) and macrophages are professional antigen-presenting cells (APCs)
that play key roles in both innate and adaptive immunity. ChemR23 is an orphan G protein …

Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming

A Martín-Fontecha, S Sebastiani… - The Journal of …, 2003 - rupress.org
Antigen-pulsed dendritic cells (DCs) are used as natural adjuvants for vaccination, but the
factors that influence the efficacy of this treatment are poorly understood. We investigated …

Vaccination of advanced hepatocellular carcinoma patients with tumor lysate-pulsed dendritic cells: a clinical trial

WC Lee, HC Wang, CF Hung, PF Huang… - Journal of …, 2005 - journals.lww.com
Hepatocellular carcinoma (HCC) is a common and rapidly progressing malignancy. Current
treatment options for advanced HCC are limited. This clinical study of dendritic cell (DC) …

In Situ Tumor Ablation Creates an Antigen Source for the Generation of Antitumor Immunity

MH Den Brok, RPM Sutmuller, R van der Voort… - Cancer research, 2004 - AACR
Tumor-destructing techniques, like radiofrequency ablation (RFA), allow eradication of large
tumors. Potentially, in situ tumor destruction also can provide the immune system with an …

Dendritic cell infiltration and prognosis of early stage breast cancer

I Treilleux, JY Blay, N Bendriss-Vermare… - Clinical Cancer …, 2004 - AACR
Purpose: Although dendritic cells (DC) and T cells can infiltrate primary breast carcinoma, it
remains unclear whether the immune response influences the clinical outcome …

Cancer immunotherapy: nanodelivery approaches for immune cell targeting and tracking

J Conniot, JM Silva, JG Fernandes, LC Silva… - Frontiers in …, 2014 - frontiersin.org
Cancer is one of the most common diseases afflicting people globally. New therapeutic
approaches are needed due to the complexity of cancer as a disease. Many current …

Overview of the actions of glucocorticoids on the immune response: a good model to characterize new pathways of immunosuppression for new treatment strategies

D Franchimont - Annals of the New York Academy of Sciences, 2004 - Wiley Online Library
Glucocorticoids have been used for over 50 years in the treatment of inflammatory and
autoimmune diseases and in preventing graft rejection. Today, knowledge of their …