Asymmetric organocatalysis: an enabling technology for medicinal chemistry

B Han, XH He, YQ Liu, G He, C Peng… - Chemical Society Reviews, 2021 - pubs.rsc.org
The efficacy and synthetic versatility of asymmetric organocatalysis have contributed
enormously to the field of organic synthesis since the early 2000s. As asymmetric …

A high-stringency blueprint of the human proteome

S Adhikari, EC Nice, EW Deutsch, L Lane… - Nature …, 2020 - nature.com
Abstract The Human Proteome Organization (HUPO) launched the Human Proteome Project
(HPP) in 2010, creating an international framework for global collaboration, data sharing …

Towards the overcoming of anticancer drug resistance mediated by p53 mutations

X Cao, J Hou, Q An, YG Assaraf, X Wang - Drug Resistance Updates, 2020 - Elsevier
Cancer continues to be a leading threat to human health and life. Resistance to anti-cancer
drugs is a major impediment towards efficacious cancer treatment. p53 mutations play an …

Seeing the complete picture: proteins in top-down mass spectrometry

T Habeck, F Lermyte - Essays in Biochemistry, 2023 - portlandpress.com
Top-down protein mass spectrometry can provide unique insights into protein sequence and
structure, including precise proteoform identification and study of protein–ligand and protein …

Polystyrene microplastics mediate cell cycle arrest, apoptosis, and autophagy in the G2/M phase through ROS in grass carp kidney cells

H Lu, L Hou, Y Zhang, T Guo, Y Wang… - Environmental …, 2024 - Wiley Online Library
Microplastics (MPs) have attracted widespread worldwide attention as a new pollutant.
However, the role of reactive oxygen species (ROS) and cell cycle in nephrotoxicity induced …

The human melanoma proteome atlas—Complementing the melanoma transcriptome

LH Betancourt, J Gil, A Sanchez… - Clinical and …, 2021 - Wiley Online Library
The MM500 meta‐study aims to establish a knowledge basis of the tumor proteome to serve
as a complement to genome and transcriptome studies. Somatic mutations and their effect …

Clinical challenges of tissue preparation for spatial transcriptome

X Liu, Y Jiang, D Song, L Zhang, G Xu… - Clinical and …, 2022 - Wiley Online Library
Spatial transcriptomics is considered as an important part of spatiotemporal molecular
images to bridge molecular information with clinical images. Of those potentials and …

The human melanoma proteome atlas—Defining the molecular pathology

LH Betancourt, J Gil, Y Kim, V Doma… - Clinical and …, 2021 - Wiley Online Library
The MM500 study is an initiative to map the protein levels in malignant melanoma tumor
samples, focused on in‐depth histopathology coupled to proteome characterization. The …

[HTML][HTML] Towards precision dermatology: emerging role of proteomic analysis of the skin

G Fredman, L Skov, M Mann, B Dyring-Andersen - Dermatology, 2022 - karger.com
Background: The skin is the largest organ in the human body and serves as a multilayered
protective shield from the environment as well as a sensor and thermal regulator. However …

[HTML][HTML] The role of neutrophil extracellular traps in cancer metastasis

W Wang, J Zhang, N Zheng, L Li, X Wang… - Clinical and …, 2020 - ncbi.nlm.nih.gov
Extracellular traps are web-like structures and consist of chromatin DNA filaments, histones,
and granule proteins. These are released together with inflammatory mediators and …