Colorectal carcinoma is one of the most common cancers and one of the leading causes of
cancer-related death in the United States. Pathologic examination of biopsy, polypectomy …

Cellular energy is primarily provided by the oxidative degradation of nutrients coupled with
mitochondrial respiration, in which oxygen participates in the mitochondrial electron …

In the past decade, studies of the human tumour suppressor LKB1 have uncovered a novel
signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 …

Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

Colorectal cancer (CRC) accounts for over 8% of all deaths annually worldwide. Between 2
and 5% of all CRCs occur due to inherited syndromes, including Lynch syndrome, familial …

Compared with many normal tissues, cancer cells are highly sensitized to apoptotic signals,
and survive only because they have acquired lesions—such as loss of p53—that prevent or …

Peutz–Jeghers syndrome (PJS, MIM175200) is an autosomal dominant condition defined by
the development of characteristic polyps throughout the gastrointestinal tract and …

The initial insight into the genetic basis of apoptosis, or programmed cell death, was gained
from ingenious studies of the roundworm Caenorhabditis elegans (for review, see Horvitz …

Abstract Autophagy-related gene (Atg) 5 is a gene product required for the formation of
autophagosomes. Here, we report that Atg5, in addition to the promotion of autophagy …

Cell growth and proliferation requires an intricate coordination between the stimulatory
signals arising from nutrients and growth factors and the inhibitory signals arising from …