Oxidative stress (OS) arises as a consequence of an imbalance between the formation of
reactive oxygen species (ROS) and the capacity of antioxidant defense mechanisms to …

As a classic animal model of Alzheimer's disease (AD), the 3× Tg-AD mouse not only
recapitulates most of anatomical hallmarks observed in AD pathology but also displays …

A multifaceted approach can be effective for the treatment of dementia including the most
common form, Alzheimer's disease (AD). However, currently, it involves only symptomatic …

Fear learning and memory are crucial for animal survival. Abnormal fear memory is a
hallmark of many neuropsychiatric disorders. Appropriate neuronal activation and …

Background: Cognitive deficit is mainly clinical characteristic of Alzheimer's disease (AD).
Recent reports showed adiponectin and its analogues could reverse cognitive impairments …

The 4-(phenylsulfanyl) butan-2-one (4-PSB-2), a marine-derived compound from soft coral,
was proven to have multiple biological activities including neuroprotection and potent anti …

Alzheimer's disease (AD) is a progressive brain disease that causes cognitive impairment in
seniors. The beta-amyloid (Aβ) deposition and intracellular neurofibrillary tangles are two …

Alzheimer's disease (AD) is one of the most common progressive neurodegenerative
disorders that cause deterioration of cognitive functions. Recent studies suggested that the …

ECa 233 is a standardized extract of Centella asiatica (CA), an herb widely used in
traditional Chinese and Ayurvedic medicine. Previous studies reported that ECa 233 …

Background One intrastriatal administration of quinolinic acid (QA) in rats induces a lesion
with features resembling those observed in Huntington's disease. Our aim is to evaluate the …