Migraine is a neurological disorder defined by episodic attacks of chronic pain associated
with nausea, photophobia, and phonophobia. It is known to be a complex disease with …

Research on GPR34, which was discovered in 1999 as an orphan G protein-coupled
receptor of the rhodopsin-like class, disclosed its physiologic relevance only piece by piece …

Migraine is a common disabling neurovascular brain disorder typically characterised by
attacks of severe headache and associated with autonomic and neurological symptoms …

Familial hemiplegic migraine type 1 (FHM1) is a rare monogenic subtype of migraine with
aura caused by mutations in CACNA1A that encodes the α 1A subunit of voltage-gated Ca V …

Background Blocking the pro-nociceptive action of CGRP is one of the most promising
approaches for migraine prophylaxis. The aim of this study was to explore a role for CGRP …

Gain-of-function mutations in the human CaV2. 1 gene CACNA1A cause familial hemiplegic
migraine type 1 (FHM1). To characterize cellular problems potentially triggered by CaV2. 1 …

Migraine, an extremely disabling neurological disorder, has a strong genetic component.
Since monogenic migraines (resulting from mutations or changes in a single gene) may help …

Background Migraine is a common episodic brain disorder characterized by recurrent
attacks of severe unilateral headache and additional neurological symptoms. Two main …

Epigenetic mechanisms affect gene expression and thereby may underlie disease
pathology, but this has not been investigated in any great detail for migraine. Unfortunately …

Neurons are specialized cells that communicate via electrical and chemical signaling. It is
well-known that homeostatic mechanisms exist to potentiate neuronal output when activity …