Irinotecan has been used in the treatment of various malignancies for many years. Still, the
knowledge regarding this drug is expanding. The pharmacogenetics of the drug is the …

Background: Cancer continues to be the most annihilating illness and despite vast research
in understanding cancer biology as well as rational drug designing progressing profoundly …

Acetylation and PEGylation can decrease cytotoxicity, improve biocompatibility, and reduce
the rate of PAMAM dendrimers elimination from systemic circulation. However, there is …

The non-selective cytotoxicity of toxins limits the clinical relevance of the toxins. In recent
years, toxins have been widely used as warheads for antibody‒drug conjugates (ADCs) …

Conventional chemotherapy is effective for metastatic tumors widely present in colorectal
cancer patients; however, chemotherapy may cause severe systemic toxicity due to a lack of …

Objective Colorectal cancer is one of the most deadly cancers in the world. Docetaxel (DTX)
is a potentially important chemotherapeutic agent for the treatment of cancer. Many studies …

Acute pancreatitis is a sudden inflammation and only last for a short time, but might lead to a
life-threatening emergency. Traditional drug therapy is an essential supportive method for …

Acute pancreatitis (AP) is a complex inflammatory disease caused by multiple etiologies, the
pathogenesis of which has not been fully elucidated. Oxidative stress is important for the …

The development of gene delivery systems is essential to improve their transfection
efficiency and cytotoxicity. Combination of lipid and polymeric nanoparticles with the …

Cancer, a widespread and lethal disease, necessitates precise therapeutic interventions to
mitigate its devastating impact. While conventional chemotherapy remains a cornerstone of …