Alzheimer's disease (AD) is caused by synaptic and neuronal loss in the brain. One of the
characteristic hallmarks of AD is senile plaques containing amyloid β-peptide (Aβ). Aβ is …

Proteolytic removal of membrane protein ectodomains (ectodomain shedding) is a post‐
translational modification that controls levels and function of hundreds of membrane …

Proteolysis of the amyloid precursor protein (APP) liberates various fragments including the
proposed initiator of Alzheimer disease-associated dysfunctions, amyloid-β. However …

As the nervous system develops, newly differentiated neurons need to extend their axons
toward their synaptic targets to form functional neural circuits. During this highly dynamic …

The SPFH (stomatin, prohibitin, flotillin, HflC/K) superfamily is composed of scaffold proteins
that form ring‐like structures and locally specify the protein–lipid composition in a variety of …

Abstract Alzheimer's disease (AD), which is predicted to affect 1 in 85 persons worldwide by
2050, results in progressive loss of neuronal functions, leading to impairments in memory …

Abstract γ-Secretase cleavage is essential for many biological processes and its
dysregulation is linked to disease, including cancer and Alzheimer's disease. Therefore …

Introduction Identifying CSF‐based biomarkers for the β‐amyloidosis that initiates
Alzheimer's disease (AD) could provide inexpensive and dynamic tests to distinguish AD …

ADAM10 (A Disintegrin and Metalloproteinase 10) has been identified as the major
physiological alpha-secretase in neurons, responsible for cleaving APP in a non …

Brain-derived neurotrophic factor (BDNF) is an important modulator for a variety of functions
in the central nervous system (CNS). A wealth of evidence, such as reduced mRNA and …