[HTML][HTML] High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragments

G Wang, B Mishra, RF Epand, RM Epand - Biochimica et Biophysica Acta …, 2014 - Elsevier
Host defense antimicrobial peptides are key components of human innate immunity that
plays an indispensible role in human health. While there are multiple copies of cathelicidin …

Anti-bacterial activity of inorganic nanomaterials and their antimicrobial peptide conjugates against resistant and non-resistant pathogens

DM Pardhi, DŞ Karaman, J Timonen, W Wu… - International journal of …, 2020 - Elsevier
This review details the antimicrobial applications of inorganic nanomaterials of mostly
metallic form, and the augmentation of activity by surface conjugation of peptide ligands. The …

Real-time attack on single Escherichia coli cells by the human antimicrobial peptide LL-37

KA Sochacki, KJ Barns, R Bucki… - Proceedings of the …, 2011 - National Acad Sciences
Natural antimicrobial peptides (AMPs) provide prototypes for the design of unconventional
antimicrobial agents. Existing bulk assays measure AMP activity but do not provide details of …

LL-37-derived short antimicrobial peptide KR-12-a5 and its d-amino acid substituted analogs with cell selectivity, anti-biofilm activity, synergistic effect with …

EY Kim, G Rajasekaran, SY Shin - European journal of medicinal chemistry, 2017 - Elsevier
Abstract KR-12-a5 is a 12-meric α-helical antimicrobial peptide (AMP) with dual
antimicrobial and anti-inflammatory activities designed from human cathelicidin LL-37. We …

Molecular dynamics simulations of human antimicrobial peptide LL-37 in model POPC and POPG lipid bilayers

L Zhao, Z Cao, Y Bian, G Hu, J Wang… - International journal of …, 2018 - mdpi.com
Cathelicidins are a large family of cationic antimicrobial peptides (AMPs) found in mammals
with broad spectrum antimicrobial activity. LL-37 is the sole amphipathic α-helical AMP from …

[HTML][HTML] Interaction of heat shock protein 70 with membranes depends on the lipid environment

G Armijo, J Okerblom, DM Cauvi, V Lopez… - Cell Stress and …, 2014 - Elsevier
Heat shock proteins (hsp) are well recognized for their protein folding activity. Additionally,
hsp expression is enhanced during stress conditions to preserve cellular homeostasis. Hsp …

Structural plasticity of LL-37 indicates elaborate functional adaptation mechanisms to bacterial target structures

K Zeth, E Sancho-Vaello - International Journal of Molecular Sciences, 2021 - mdpi.com
The human cathelicidin LL-37 is a multifunctional peptide of the human innate immune
system. Among the various functions of LL-37, its antimicrobial activity is important in …

Insights into protein structure and dynamics by ultraviolet and visible resonance Raman spectroscopy

I López-Peña, BS Leigh, DE Schlamadinger… - Biochemistry, 2015 - ACS Publications
Raman spectroscopy is a form of vibrational spectroscopy based on inelastic scattering of
light. In resonance Raman spectroscopy, the wavelength of the incident light falls within an …

The Functionality of Membrane-Inserting Proteins and Peptides: Curvature Sensing, Generation, and Pore Formation

C Has, SL Das - The Journal of Membrane Biology, 2023 - Springer
Proteins and peptides with hydrophobic and amphiphilic segments are responsible for many
biological functions. The sensing and generation of membrane curvature are the functions of …

The effect of chitosan and PEG polymers on stabilization of GF-17 structure: a molecular dynamics study

H Asadzadeh, A Moosavi, JH Arghavani - Carbohydrate polymers, 2020 - Elsevier
We examine the interactions of chitosan and polyethylene glycol (PEG) with antimicrobial
peptide GF-17 to identify a suitable carrier to improve the peptide drug delivery systems. To …