[HTML][HTML] High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragments
Host defense antimicrobial peptides are key components of human innate immunity that
plays an indispensible role in human health. While there are multiple copies of cathelicidin …
plays an indispensible role in human health. While there are multiple copies of cathelicidin …
Anti-bacterial activity of inorganic nanomaterials and their antimicrobial peptide conjugates against resistant and non-resistant pathogens
This review details the antimicrobial applications of inorganic nanomaterials of mostly
metallic form, and the augmentation of activity by surface conjugation of peptide ligands. The …
metallic form, and the augmentation of activity by surface conjugation of peptide ligands. The …
Real-time attack on single Escherichia coli cells by the human antimicrobial peptide LL-37
KA Sochacki, KJ Barns, R Bucki… - Proceedings of the …, 2011 - National Acad Sciences
Natural antimicrobial peptides (AMPs) provide prototypes for the design of unconventional
antimicrobial agents. Existing bulk assays measure AMP activity but do not provide details of …
antimicrobial agents. Existing bulk assays measure AMP activity but do not provide details of …
LL-37-derived short antimicrobial peptide KR-12-a5 and its d-amino acid substituted analogs with cell selectivity, anti-biofilm activity, synergistic effect with …
EY Kim, G Rajasekaran, SY Shin - European journal of medicinal chemistry, 2017 - Elsevier
Abstract KR-12-a5 is a 12-meric α-helical antimicrobial peptide (AMP) with dual
antimicrobial and anti-inflammatory activities designed from human cathelicidin LL-37. We …
antimicrobial and anti-inflammatory activities designed from human cathelicidin LL-37. We …
Molecular dynamics simulations of human antimicrobial peptide LL-37 in model POPC and POPG lipid bilayers
L Zhao, Z Cao, Y Bian, G Hu, J Wang… - International journal of …, 2018 - mdpi.com
Cathelicidins are a large family of cationic antimicrobial peptides (AMPs) found in mammals
with broad spectrum antimicrobial activity. LL-37 is the sole amphipathic α-helical AMP from …
with broad spectrum antimicrobial activity. LL-37 is the sole amphipathic α-helical AMP from …
[HTML][HTML] Interaction of heat shock protein 70 with membranes depends on the lipid environment
G Armijo, J Okerblom, DM Cauvi, V Lopez… - Cell Stress and …, 2014 - Elsevier
Heat shock proteins (hsp) are well recognized for their protein folding activity. Additionally,
hsp expression is enhanced during stress conditions to preserve cellular homeostasis. Hsp …
hsp expression is enhanced during stress conditions to preserve cellular homeostasis. Hsp …
Structural plasticity of LL-37 indicates elaborate functional adaptation mechanisms to bacterial target structures
K Zeth, E Sancho-Vaello - International Journal of Molecular Sciences, 2021 - mdpi.com
The human cathelicidin LL-37 is a multifunctional peptide of the human innate immune
system. Among the various functions of LL-37, its antimicrobial activity is important in …
system. Among the various functions of LL-37, its antimicrobial activity is important in …
Insights into protein structure and dynamics by ultraviolet and visible resonance Raman spectroscopy
I López-Peña, BS Leigh, DE Schlamadinger… - Biochemistry, 2015 - ACS Publications
Raman spectroscopy is a form of vibrational spectroscopy based on inelastic scattering of
light. In resonance Raman spectroscopy, the wavelength of the incident light falls within an …
light. In resonance Raman spectroscopy, the wavelength of the incident light falls within an …
The Functionality of Membrane-Inserting Proteins and Peptides: Curvature Sensing, Generation, and Pore Formation
Proteins and peptides with hydrophobic and amphiphilic segments are responsible for many
biological functions. The sensing and generation of membrane curvature are the functions of …
biological functions. The sensing and generation of membrane curvature are the functions of …
The effect of chitosan and PEG polymers on stabilization of GF-17 structure: a molecular dynamics study
H Asadzadeh, A Moosavi, JH Arghavani - Carbohydrate polymers, 2020 - Elsevier
We examine the interactions of chitosan and polyethylene glycol (PEG) with antimicrobial
peptide GF-17 to identify a suitable carrier to improve the peptide drug delivery systems. To …
peptide GF-17 to identify a suitable carrier to improve the peptide drug delivery systems. To …