Many cancer type-specific anticancer agents have been developed and significant
advances have been made toward precision medicine in cancer treatment. However …

Quinolone antimicrobials are widely used in clinical medicine and are the only current class
of agents that directly inhibit bacterial DNA synthesis. Quinolones dually target DNA gyrase …

DNA topoisomerases are enzymes that control the topology of DNA in all cells. There are
two types, I and II, classified according to whether they make transient single-or double …

Covering: up to the end of 2016 Novel antimicrobial drugs are continuously needed to
counteract bacterial resistance development. An innovative molecular design strategy for …

The emergence of bacterial resistance against life-saving medicines has forced the scientific
community and pharmaceutical industry to take actions in the quest for novel antibacterials …

Background: Discovery of novel antimicrobial agents is in need to deal with antibiotic
resistance. Elucidating the mechanism of action for established drugs contributes to this …

DNA topoisomerases are proven therapeutic targets of antibacterial agents. Quinolones,
especially fluoroquinolones, are the most successful topoisomerase-targeting antibacterial …

Drug development process demands validation of specific drug target impeding the Multi
Drug Resistance (MDR). DNA gyrase, as a bacterial target has been in trend for developing …

The inhibition of pathogenic bacteria at the replication stage is important to halt their further
reproduction and spread. The replication enzymes include the DNA gyrase and …

Background: Emerging resistance of bacterial pathogens to clinically used drugs, including
not only first-choice but also second-and third-choice drugs, is alarming, but since the 1990s …