Lipid bodies in inflammatory cells: structure, function, and current imaging techniques

RCN Melo, H D'Avila, HC Wan… - … of Histochemistry & …, 2011 - journals.sagepub.com
Lipid bodies (LBs), also known as lipid droplets, have increasingly been recognized as
functionally active organelles linked to diverse biological functions and human diseases …

Lipid body–phagosome interaction in macrophages during infectious diseases: host defense or pathogen survival strategy?

RCN Melo, AM Dvorak - PLoS pathogens, 2012 - journals.plos.org
Phagocytosis of invading microorganisms by specialized cells such as macrophages and
neutrophils is a key component of the innate immune response. These cells capture and …

[HTML][HTML] Histological assessment of granulomas in natural and experimental Schistosoma mansoni infections using whole slide imaging

KB Amaral, TP Silva, FF Dias, KK Malta, FM Rosa… - PLoS …, 2017 - journals.plos.org
The pathology of schistosomiasis mansoni, a neglected tropical disease of great clinical and
socioeconomic importance, results from the parasite eggs that become trapped in host …

Lipid Body Organelles within the Parasite Trypanosoma cruzi: A Role for Intracellular Arachidonic Acid Metabolism

DAM Toledo, NR Roque, L Teixeira, EA Milán-Garcés… - PLoS …, 2016 - journals.plos.org
Most eukaryotic cells contain varying amounts of cytosolic lipidic inclusions termed lipid
bodies (LBs) or lipid droplets (LDs). In mammalian cells, such as macrophages, these lipid …

Natural Schistosoma mansoni Infection in the Wild Reservoir Nectomys squamipes Leads to Excessive Lipid Droplet Accumulation in Hepatocytes in the Absence of …

KB Amaral, TP Silva, KK Malta, LAS Carmo, FF Dias… - PLoS …, 2016 - journals.plos.org
Schistosomiasis is a neglected tropical disease of a significant public health impact. The
water rat Nectomys squamipes is one of the most important non-human hosts in the …

Identification of Piecemeal Degranulation and Vesicular Transport of MBP-1 in Liver-Infiltrating Mouse Eosinophils During Acute Experimental Schistosoma mansoni …

FF Dias, KB Amaral, KK Malta, TP Silva… - Frontiers in …, 2018 - frontiersin.org
Eosinophils have been long associated with helminthic infections, although their functions in
these diseases remain unclear. During schistosomiasis caused by the trematode …

Current and future challenges in the development of antimicrobial agents

RP Rennie - Antibiotic resistance, 2012 - Springer
Micro-organisms exist to survive. Even in the absence of antimicrobial agents, many have
determinants of resistance that may be expressed phenotypically, should the need arise …

Chronic rapamycin pretreatment modulates arginase/inducible nitric oxide synthase balance attenuating aging-dependent susceptibility to Trypanosoma cruzi …

M Pereira-Santos, E Gonçalves-Santos… - Experimental …, 2022 - Elsevier
Considering the efficacy of rapamycin in increasing lifespan and healthspan, attenuating the
aging-dependent immunological decline, we compared the evolution of Trypanosoma cruzi …

Lipid Bodies: Inflammatory Organelles Implicated in Host‐Trypanosoma cruzi Interplay during Innate Immune Responses

HD′ Avila, DAM Toledo… - Mediators of Inflammation, 2012 - Wiley Online Library
The flagellated protozoa Trypanosoma cruzi is the causal agent of Chagas′ disease, a
significant public health issue and still a major cause of morbidity and mortality in Latin …

Experimental Chagas disease. Innate immune response in Balb/c mice previously vaccinated with Trypanosoma rangeli. I. The macrophage shows immunological …

B Basso, V Marini - Immunobiology, 2014 - Elsevier
Chagas' disease, caused by Trypanosoma cruzi, is a major vector borne health problem in
Latin America and an emerging or re-emerging infectious disease in several countries …